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MSH6 antibody [EP49]

Cat No. GTX01750

Host

Rabbit

Clonality

Monoclonal

Clone Name

EP49

Isotype

IgG

Application

IHC-P

Reactivity

Human, Mouse, Rat, Dog
Package
500 μl ($389)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 1:50-1:100

Note :

IHC-P
Pretreatment of deparaffinized tissue with heat-induced epitope retrieval or enzymatic retrieval is recommended.

Not tested in other applications.

Calculated MW

153 kDa. ( Note )

Positive Control

Colon carcinoma

PROPERTIES

Form

Liquid

Buffer

Tris-HCl buffer, 0.2% BSA, < 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide corresponding to Human MSH6 aa 1-100 (N terminal)

Purification

Purified IgG

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

mutS homolog 6 , GTBP , GTMBP , HNPCC5 , HSAP , p160

Cellular Localization

Nucleus

Background

This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]

Database

Research Area

REFERENCE

REVIEW

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Package List Price ($)
$ 389