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MSH6 antibody [IHC006]

Anti-MSH6 antibody [IHC006] used in IHC (Paraffin sections) (IHC-P). GTX57188

Cat. No. GTX57188

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 IHC006

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($399)
See all MSH6 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:100-1:200

Note :

IHC-P
Heat-induced epitope retrieval (HIER) at pH 9 for 10 - 30 minutes
Not tested in other applications.

Calculated MW

153 kDa. ( Note )

Positive Control

Colon, Colon Carcinoma

PROPERTIES

Form

Liquid

Buffer

Tris buffer pH7.3-7.7, 1% BSA

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant Human MSH6 protein.

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Muts Homolog 6 , Gtbp , Gtmbp , Hnpcc5 , Hsap , P160 , Msh6

Background

This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]

Research Area

DATA IMAGES

Anti-MSH6 antibody [IHC006] used in IHC (Paraffin sections) (IHC-P). GTX57188

GTX57188 IHC-P Image

IHC-P analysis of human esophagus tissue using GTX57188 MSH6 antibody [IHC006]

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399