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MSH6 antibody

Anti-MSH6 antibody used in Western Blot (WB). GTX65844
Anti-MSH6 antibody used in IHC (Paraffin sections) (IHC-P). GTX65844
Anti-MSH6 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX65844
Anti-MSH6 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX65844
Anti-MSH6 antibody used in IHC (Paraffin sections) (IHC-P). GTX65844
Anti-MSH6 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX65844
Anti-MSH6 antibody used in IHC (Paraffin sections) (IHC-P). GTX65844

Cat No. GTX65844

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ICC/IF, IHC-P

Reactivity

Human, Mouse, Rat, Monkey
Package
100 μl ($339)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:2000
ICC/IF 1:20 - 1:100
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

153 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 0.02% sodium azide, 50% glycerol

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant funsion protein containing a sequence corresponding to amino acids 1-290 of human MSH6 (NP_000170.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

mutS homolog 6 , GTBP , GTMBP , HNPCC5 , HSAP , p160

Cellular Localization

Nucleus

Background

This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]

Database

Research Area

DATA IMAGES

Anti-MSH6 antibody used in Western Blot (WB). GTX65844

GTX65844 WB Image

WB analysis of various sample lysates using GTX65844 MSH6 antibody.
Dilution : 1:500
Loading : 25μg per lane

Anti-MSH6 antibody used in IHC (Paraffin sections) (IHC-P). GTX65844

GTX65844 IHC-P Image

IHC-P analysis of mouse testis tissue using GTX65844 MSH6 antibody.
Dilution : 1:100

Anti-MSH6 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX65844

GTX65844 ICC/IF Image

ICC/IF analysis of A549 cells using GTX65844 MSH6 antibody.

Anti-MSH6 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX65844

GTX65844 ICC/IF Image

ICC/IF analysis of GFP-RNF168 transgenic U2OS cells using GTX65844 MSH6 antibody.
Green : GFP-RNF168 fusion protein expression for DNA damage marker
Blue : DAPI

Anti-MSH6 antibody used in IHC (Paraffin sections) (IHC-P). GTX65844

GTX65844 IHC-P Image

IHC-P analysis of rat testis tissue using GTX65844 MSH6 antibody.
Dilution : 1:100

Anti-MSH6 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX65844

GTX65844 ICC/IF Image

ICC/IF analysis of HeLa cells using GTX65844 MSH6 antibody.
Blue : DAPI

Anti-MSH6 antibody used in IHC (Paraffin sections) (IHC-P). GTX65844

GTX65844 IHC-P Image

IHC-P analysis of human liver cancer tissue using GTX65844 MSH6 antibody.
Dilution : 1:100

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 339