APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500-1:2000 |
| 1:100-1:500 |
| 1:50-1:200 |
Not tested in other applications.
Calculated MW
Predict Reactivity
Rabbit, Sheep, Bovine, Dog, Pig, Horse, Xenopus(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS, 150mM NaCl, 50% Glycerol
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
A synthesized peptide derived from Human MSR1 (Accession P21757), corresponding to amino acid residues K22-L42.
Purification
Purified by antigen-affinity chromatography
From serum
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
macrophage scavenger receptor 1 , CD204 , SCARA1 , SR-A , SR-AI , SR-AII , SR-AIII , SRA , phSR1 , phSR2
Cellular Localization
Membrane
Background
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX03371 ICC/IF Image
ICC/IF analysis of PFA-fixed HepG2 cells using GTX03371 MSR1 antibody.
Red : Primary antibody
Blue : DAPI
Permeabilization : 0.1% Triton X-100
Dilution : 1:200
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GTX03371 IHC-P Image
IHC-P analysis of human urothelial cancer tissue section using GTX03371 MSR1 antibody.
Antigen retireval : Heat mediated antigen retrieval step in citrate buffer was performed.
Dilution : 1:100
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GTX03371 WB Image
WB analysis of mouse placenta tissue lysate using GTX03371 MSR1 antibody. The lane on the left was treated with the antigen-specific peptide.
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GTX03371 WB Image
WB analysis of HepG2 cell lysate using GTX03371 MSR1 antibody.
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GTX03371 IHC-P Image
IHC-P analysis of mouse liver tissue section using GTX03371 MSR1 antibody.
Antigen retireval : Heat mediated antigen retrieval step in citrate buffer was performed.
Dilution : 1:100
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GTX03371 IHC-P Image
IHC-P analysis of rat liver tissue section using GTX03371 MSR1 antibody.
Antigen retireval : Heat mediated antigen retrieval step in citrate buffer was performed.
Dilution : 1:100
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GTX03371 IHC-P Image
IHC-P analysis of rat kidney tissue section using GTX03371 MSR1 antibody.
Antigen retireval : Heat mediated antigen retrieval step in citrate buffer was performed.
Dilution : 1:100
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REFERENCE
There are currently no references for MSR1 antibody (GTX03371). Be the first to share your publications with this product.
REVIEW
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