GeneTex
United States (US)

MTBP antibody

Cat No. GTX28107

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Human
APPLICATION

Application Note

Western blot at 0.5 to 1 μg/ml and a 104 kDa band can be detected.

Calculated MW

102 kDa. ( Note )

Positive Control

K562 cell lysate.
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

0.5mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide: GAVECFEEEDSNSRESLS, corresponding to amino acids 122-139 of Human MTBP which differ from the mouse sequence by three amino acids(7).

Purification

IgG fraction

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Mdm2 Binding Protein,Mdm2Bp,Mtbp

Background

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2 (1), p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), PID/MTA2 (6) and MTBP (7), were recently discovered. The transcriptional activity of p53 is modulated by posttranslational regulations of the p53 protein including stabilization and acetylation. P53 transcriptionally activatesMDM2 gene then the translated MDM2 protein binds to p53and promotes the degradation of p53 leading to lowering the concentration of p53 protein. MDM2 inhibits both p53mediated G1 arrest and apoptosis. A recently discovered protein termed MTBP was found to bind to MDM2 and to inhibit the modulation effect of MDM2 on p53 (7). MTBP is expressed in a variety of normal tissues (7).

Database

Research Area

Package List Price ($)
$ 329