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MTH1 antibody

KO/KD
Anti-MTH1 antibody used in Western Blot (WB). GTX35216
Anti-MTH1 antibody used in Western Blot (WB). GTX35216
Anti-MTH1 antibody used in IHC (Paraffin sections) (IHC-P). GTX35216
Anti-MTH1 antibody used in Immunoprecipitation (IP). GTX35216

Cat. No. GTX35216

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, IP

Reactivity

 Human
Package
100 μl ($399)
See all MTH1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:200
IP 1:20 - 1:50
Not tested in other applications.

Calculated MW

23 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human NUDT1 (NP_945192.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

nudix hydrolase 1 , MTH1

Cellular Localization

Mitochondrion matrix,Nucleus

Background

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-MTH1 antibody used in Western Blot (WB). GTX35216

GTX35216 WB Image

KO/KD

WB analysis of normal (control) and knockout (KO) 293T cell lysate using GTX35216 MTH1 antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-MTH1 antibody used in Western Blot (WB). GTX35216

GTX35216 WB Image

WB analysis of various sample lysates using GTX35216 MTH1 antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-MTH1 antibody used in IHC (Paraffin sections) (IHC-P). GTX35216

GTX35216 IHC-P Image

IHC-P analysis of human gastric cancer tissue using GTX35216 MTH1 antibody.
Dilution : 1:100

Anti-MTH1 antibody used in Immunoprecipitation (IP). GTX35216

GTX35216 IP Image

IP analysis of 293T cell lysate using GTX35216 MTH1 antibody.
Antibody amount : 1μg / 200μg lysate
Dilution : 1:1000

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399