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MUC1 antibody [E29]

Anti-MUC1 antibody [E29] used in IHC (Paraffin sections) (IHC-P). GTX34857

Cat. No. GTX34857

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 E29

Isotype

 IgG2a

Application

 IHC-P

Reactivity

 Human
Package
100 μg ($529)
See all MUC1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1-2μg/ml for 30 min at RT

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes.
Not tested in other applications.

Calculated MW

122 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Delipidated extract of human milk fat globule membranes

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ADMCKD , ADMCKD1 , CA 153 , CD227 , EMA , H23AG , KL6 , MAM6 , MCD , MCKD , MCKD1 , MUC1 , MUC1/SEC , MUC1/X , MUC1/ZD , PEM , PEMT , PUM , mucin 1, cell surface associated , Mucin1 , CA15-3 , CA15.3

Cellular Localization

Apical cell membrane,Secreted,Cell membrane,Cytoplasm,Nucleus

Background

This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

Database

Research Area

DATA IMAGES

Anti-MUC1 antibody [E29] used in IHC (Paraffin sections) (IHC-P). GTX34857

GTX34857 IHC-P Image

IHC-P analysis of human breast carcinoma tissue using GTX34857 MUC1 antibody [E29].

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 529