GeneTex
United States (US)

MUC1 antibody (ready-to-use)

MUC1-antibody-ready-to-use_IHC-P_GTX15482-1_18121411_419.jpg

Cat No. GTX15482

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application IHC-P
Reactivity Human, Mouse
APPLICATION

Application Note

IHC-P: Ready to use. Antigen retrieval is not essential but may optimise staining. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

122 kDa. ( Note )

Positive Control

MCF-7 cells, Breast carcinoma
PROPERTIES

Form

Liquid

Buffer

PBS, pH 7.4 containing 1%BSA and 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (Human), cytoplasmic tail.

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Mucin 1, Cell Surface Associated,Admckd,Admckd1,Ca 15-3,Cd227,Ema,H23Ag,Kl-6,Mam6,Mcd,Mckd,Mckd1,Muc-1,Muc-1/Sec,Muc-1/X,Muc1/Zd,Pem,Pemt,Pum,Muc1

Cellular Localization

Cell Membrane and Cytoplasmic

Background

MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC-1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells.

Database

Research Area

DATA IMAGES
MUC1-antibody-ready-to-use_IHC-P_GTX15482-1_18121411_419.jpg

GTX15482 IHC-P Image

Human Breast Carcinoma stained with anti-MUC-1/EMA/Epithelial Membrane Antigen antibody (GTX15481)