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MUC1 antibody (ready-to-use)

Anti-MUC1 antibody (ready-to-use) used in IHC (Paraffin sections) (IHC-P). GTX15482

Cat. No. GTX15482

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human, Mouse
Package
7 ml ($399)
See all MUC1 products

APPLICATION

Application Note

IHC-P: Ready to use. Antigen retrieval is not essential but may optimise staining. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

122 kDa. ( Note )

Positive Control

MCF-7 cells, Breast carcinoma

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (Human), cytoplasmic tail.

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

mucin 1, cell surface associated , ADMCKD , ADMCKD1 , CA 15-3 , CD227 , EMA , H23AG , KL-6 , MAM6 , MCD , MCKD , MCKD1 , MUC-1 , MUC-1/SEC , MUC-1/X , MUC1/ZD , PEM , PEMT , PUM

Cellular Localization

Apical cell membrane , Cytoplasm , Nucleus

Background

This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

Database

Research Area

DATA IMAGES

Anti-MUC1 antibody (ready-to-use) used in IHC (Paraffin sections) (IHC-P). GTX15482

GTX15482 IHC-P Image

Human Breast Carcinoma stained with anti-MUC-1/EMA/Epithelial Membrane Antigen antibody (GTX15481)

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399