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MUC1 antibody

Anti-MUC1 antibody used in IHC (Paraffin sections) (IHC-P). GTX15481

Cat No. GTX15481

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P

Reactivity

Human, Mouse
Package
500 μl ($349)

APPLICATION

Application Note

Recommended Starting Dilutions:
For ICC/IF: Use at a dilution of 1:500
For IHC-P: Use at a dilution of 1:100. No special pretreatment is required for immunohistochemistry.
For IP: Use at an assay dependent dilutions.
For WB: Use at an assay dependent dilution.
Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

122 kDa. ( Note )

Positive Control

MCF-7 cells and Breast carcinoma

PROPERTIES

Form

Liquid

Buffer

PBS pH7.4, 1% BSA

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The immunogen corresponding to a region within amino acid 1067 and 1255 of human MUC1 (Swiss-Prot entry P15941).

Purification

Immunogen affinity purified
From polyclonal serum

Conjugation

Unconjugated

RRID

AB_368636

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

mucin 1, cell surface associated , ADMCKD , ADMCKD1 , CA 15-3 , CD227 , EMA , H23AG , KL-6 , MAM6 , MCD , MCKD , MCKD1 , MUC-1 , MUC-1/SEC , MUC-1/X , MUC1/ZD , PEM , PEMT , PUM

Cellular Localization

Apical cell membrane , Cytoplasm , Nucleus

Background

This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

Database

Research Area

DATA IMAGES

Anti-MUC1 antibody used in IHC (Paraffin sections) (IHC-P). GTX15481

GTX15481 IHC-P Image

Human Breast Carcinoma stained with anti-MUC-1/EMA/Epithelial Membrane Antigen antibody (GTX15481)

REFERENCE

REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 349