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MUC2 antibody [C3], C-term

Anti-MUC2 antibody [C3], C-term used in IHC (Paraffin sections) (IHC-P). GTX100664
Anti-MUC2 antibody [C3], C-term used in IHC (Paraffin sections) (IHC-P). GTX100664
Anti-MUC2 antibody [C3], C-term used in IHC (Paraffin sections) (IHC-P). GTX100664

Cat No. GTX100664

Reference 8
Host Rabbit
Clonality Polyclonal
Isotype IgG
Application ICC/IF, IHC-P, IHC-Fr, IHC
Reactivity Human, Mouse
Package
100 μl ($319),
25 μl ($169)
See all MUC2 products
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF 1:100-1:1000
IHC-P 1:100-1:1000
IHC-Fr Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

540 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.48 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human MUC2. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

mucin 2, oligomeric mucus/gel-forming,MLP,MUC-2,SMUC

Cellular Localization

Secreted

Background

This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq]

Database

  • Gene ID: 4583 MUC2

Research Area

DATA IMAGES
Anti-MUC2 antibody [C3], C-term used in IHC (Paraffin sections) (IHC-P). GTX100664

GTX100664 IHC-P Image

MUC2 antibody [C3], C-term detects secreted MUC2 protein by immunohistochemical analysis.
Sample: Paraffin-embedded mouse colon.
MUC2 stained by MUC2 antibody [C3], C-term (GTX100664) diluted at 1:2000.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
Anti-MUC2 antibody [C3], C-term used in IHC (Paraffin sections) (IHC-P). GTX100664

GTX100664 IHC-P Image

MUC2 antibody [C3], C-term detects secreted MUC2 protein by immunohistochemical analysis.
Sample: Paraffin-embedded mouse intestine.
MUC2 stained by MUC2 antibody [C3], C-term (GTX100664) diluted at 1:2000.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
Anti-MUC2 antibody [C3], C-term used in IHC (Paraffin sections) (IHC-P). GTX100664

GTX100664 IHC-P Image

MUC2 antibody [C3], C-term detects secreted MUC2 protein in human intestine by immunohistochemical analysis.
Sample: Paraffin-embedded human intestine.
MUC2 antibody [C3], C-term (GTX100664) diluted at 1:750.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
REFERENCE

Application Reference

Hwang D et al. Food Chem Toxicol 2018; 118 : 880-888 Oxyresveratrol stimulates mucin production in an NAD+-dependent manner in human intestinal goblet cells.
Application : ICC/IF
Reactivity : Human
Ozcan HEA et al. Adv Med Sci 2018; 63 (2) : 296-300 Expression profile and cellular localizations of mucin proteins, CK7, and cytoplasmic p27 in Barrett's esophagus and esophageal adenocarcinoma.
Application : IHC-P
Reactivity : Human
Jinfang et al. Digestive and Liver Disease 2018; (Epub) Peroxisome Proliferator-activated Receptor Gamma Activation Promotes Intestinal Barrier Function by Improving Mucus and Tight Junctions in a Mouse Colitis Model.
Application : IHC-P
Reactivity : Mouse
Sun C et al. Inflamm Bowel Dis 2017; 23 (8) : 1338-1347 Cideb Deficiency Aggravates Dextran Sulfate Sodium-induced Ulcerative Colitis in Mice by Exacerbating the Oxidative Burden in Colonic Mucosa.
Application : IHC-P
Reactivity : Mouse
Hwang D et al. J Funct Foods 2017; 35 : 146-158 Oxyresveratrol-containing Ramulus mori ethanol extract attenuates acute colitis by suppressing inflammation and increasing mucin secretion.
Application : ICC/IF
Reactivity : Human
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Application Reference
Hwang D et al. Food Chem Toxicol 2018; 118:880-888 Oxyresveratrol stimulates mucin production in an NAD+-dependent manner in human intestinal goblet cells.
Application : ICC/IF
Reactivity : Human
Ozcan HEA et al. Adv Med Sci 2018; 63 (2):296-300 Expression profile and cellular localizations of mucin proteins, CK7, and cytoplasmic p27 in Barrett's esophagus and esophageal adenocarcinoma.
Application : IHC-P
Reactivity : Human
Jinfang et al. Digestive and Liver Disease 2018; (Epub) Peroxisome Proliferator-activated Receptor Gamma Activation Promotes Intestinal Barrier Function by Improving Mucus and Tight Junctions in a Mouse Colitis Model.
Application : IHC-P
Reactivity : Mouse
Sun C et al. Inflamm Bowel Dis 2017; 23 (8):1338-1347 Cideb Deficiency Aggravates Dextran Sulfate Sodium-induced Ulcerative Colitis in Mice by Exacerbating the Oxidative Burden in Colonic Mucosa.
Application : IHC-P
Reactivity : Mouse
Hwang D et al. J Funct Foods 2017; 35:146-158 Oxyresveratrol-containing Ramulus mori ethanol extract attenuates acute colitis by suppressing inflammation and increasing mucin secretion.
Application : ICC/IF
Reactivity : Human
Usui T et al. Stem Cells International 2016; 2016:Article ID 7053872 Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment.
Application : ICC/IF
Reactivity : Human
Wang K et al. Immunity 2014; 41 (6):1052-63 Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis.
Application : IHC-Fr
Reactivity : Mouse
Grivennikov SI et al. Nature 2012; 491 (7423):254-8 Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Application : IHC
Reactivity : Human
SDS
PBS.pdf
Glycerol.pdf
Proclin.pdf
Package List Price ($)
$ 319
$ 169