GeneTex
United States (US)

MUC2 antibody [MLP/842]

GTX34867_20170712_IHC-P_18121410_293.jpg
GTX34867_20170712_IHC-P_1_18121410_126.jpg

Cat No. GTX34867

Host Mouse
Clonality Monoclonal
Clone Name MLP/842
Isotype IgG1
Application IHC-P
Reactivity Human
APPLICATION

Application Note

IHC-P:0.5-1ug/ml for 30 minutes at RT.

Calculated MW

540 kDa. ( Note )

Specificity/Sensitivity

Recognizes a single glycoprotein of 520kDa, identified as mucin 2 (MUC2). This MAb shows no cross-reaction with human milk fat globule membranes, MUC1, or MUC3. Mucins are high molecular weight glycoproteins, which constitute the major component of the mucus layer that protects the gastric epithelium. MUC2 is specifically expressed in goblet cells of the small intestine & colon; in about 65% of colonic carcinomas and about 40% of gastric carcinomas. MUC2 is rarely expressed outside of the GI tract with the exceptions of mucinous carcinoma of breast and clear cell-type carcinomas of the ovary.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant fragment covering tandem repeats of human MUC2 protein (exact sequence is proprietary)

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Mucin 2, Oligomeric Mucus/Gel-Forming,Mlp,Muc-2,Smuc,Muc2

Background

This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
GTX34867_20170712_IHC-P_18121410_293.jpg

GTX34867 IHC-P Image

Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with MUC2 Monoclonal Antibody (MLP/842).

GTX34867_20170712_IHC-P_1_18121410_126.jpg

GTX34867 IHC-P Image

Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with MUC2 Monoclonal Antibody (MLP/842).

Package List Price ($)
$ 329