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MUS81 antibody

Anti-MUS81 antibody used in Western Blot (WB). GTX03656

Cat. No. GTX03656

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($429)
See all MUS81 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.25-0.5 μg/ml
ELISA 0.1-0.5 μg/ml
Not tested in other applications.

Calculated MW

61 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

4mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

E.coli-derived human MUS81 recombinant protein (Position: H283-R483).

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

MUS81 structure-specific endonuclease subunit , SLX3

Cellular Localization

Nucleolus

Background

This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks. [provided by RefSeq, Jun 2017]

Database

Research Area

DATA IMAGES

Anti-MUS81 antibody used in Western Blot (WB). GTX03656

GTX03656 WB Image

WB analysis of various sample lysates using GTX03656 MUS81 antibody.
Lane 1 : HeLa whole cell lysates
Lane 2 : A431 whole cell lysates
Lane 3 : HepG2 whole cell lysates
Lane 4 : rat brain tissue lysates
Lane 5 : PC-12 whole cell lysates
Lane 6 : brain tissue lysates
Lane 7 : NIH/3T3 whole cell lysates

REFERENCE

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REVIEW

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Package List Price ($)
$ 429