MUTYH antibody

Cat. No. GTX03360

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, ICC/IF, FACS
Reactivity	Human, Mouse
Package	400 μl ($399)

See all MUTYH products

Datasheet

View product citations for antibody GTX03360 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1:1000
ICC/IF	1:10-1:50
FACS	1:10-1:50

Not tested in other applications.

Calculated MW

60 kDa. ( Note )

Predict Reactivity

Rabbit, Sheep, Bovine, Dog(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide between 341-367 amino acids from the Central region of human MUTYH.

Purification

Purified by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

mutY DNA glycosylase , MYH

Cellular Localization

Nucleus , Mitochondrion

Background

This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]

Database

Gene ID: 4595 MUTYH
UniProt: Q9UIF7 MUTYH

Research Area

DATA IMAGES

GTX03360 FACS Image

FACS analysis of NCI-H460 cells (bottom histogram) compared to a negative control cell (top histogram) using GTX03360 MUTYH antibody.

GTX03360 ICC/IF Image

ICC/IF analysis of HeLa cells using GTX03360 MUTYH antibody.
Green : Primary antibody
Blue : DAPI

GTX03360 WB Image

WB analysis of mouse lung tissue lysate (35μg/lane) using GTX03360 MUTYH antibody.

REFERENCE

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REVIEW

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Package

List Price ($)

400 μl

$ 399

Qty