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MUTYH antibody

Anti-MUTYH antibody used in IHC (Paraffin sections) (IHC-P). GTX66680
Anti-MUTYH antibody used in Western Blot (WB). GTX66680

Cat. No. GTX66680

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all MUTYH products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:1000
IHC-P 1:50-1:200
Not tested in other applications.

Calculated MW

60 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide, corresponding to amino acids 142-190 of Human MYH.

Purification

Purified by antigen-affinity chromatography
From serum

Purity

> 95% (by SDS-PAGE)

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

mutY DNA glycosylase , MYH

Cellular Localization

Nucleus,Mitochondrion

Background

This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]

Database

Research Area

DATA IMAGES

Anti-MUTYH antibody used in IHC (Paraffin sections) (IHC-P). GTX66680

GTX66680 IHC-P Image

IHC-P analysis of human breast carcinoma tissue using GTX66680 MUTYH antibody.
Dilution : 1:50

Anti-MUTYH antibody used in Western Blot (WB). GTX66680

GTX66680 WB Image

WB analysis of various samples using GTX66680 MUTYH antibody.
Lane1 : K562 whole cell lysate(40ug)
Lane2 : U-87MG whole cell lysate(40ug)
Lane3 : C6 whole cell lysate(40ug)
Lane4 : AML-12 whole cell lysate(40ug)
Dilution : 1:500

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399