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MVP/LRP antibody [C2C3], C-term

KO/KD
Anti-MVP/LRP antibody [C2C3], C-term used in Western Blot (WB). GTX100536
Anti-MVP/LRP antibody [C2C3], C-term used in Western Blot (WB). GTX100536
Anti-MVP/LRP antibody [C2C3], C-term used in IHC (Paraffin sections) (IHC-P). GTX100536

Cat No. GTX100536

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human, Mouse
Package
100 μl ($319),
25 μl ($169)
See all MVP/LRP products
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:3000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

99 kDa. ( Note )

Positive Control

HeLa , NIH-3T3

Predict Reactivity

Rat, Bovine, Cat, Dog(>80% identity)
PROPERTIES

Form

Liquid

Buffer

1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the C-terminus region of human MVP/LRP. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

major vault protein,LRP,VAULT1

Cellular Localization

Cytoplasm , Nucleus , nuclear pore complex

Background

This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts. [provided by RefSeq]

Database

DATA IMAGES
Anti-MVP/LRP antibody [C2C3], C-term used in Western Blot (WB). GTX100536

GTX100536 WB Image

KO/KD

Wild-type (WT) and MVP/LRP knockout (KO) HeLa cell extracts (30 µg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with MVP/LRP antibody [C2C3], C-term (GTX100536) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
Anti-MVP/LRP antibody [C2C3], C-term used in Western Blot (WB). GTX100536

GTX100536 WB Image

Sample (30 µg of whole cell lysate)
A:NIH-3T3
7.5% SDS PAGE
GTX100536 diluted at 1:1000
The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
Anti-MVP/LRP antibody [C2C3], C-term used in IHC (Paraffin sections) (IHC-P). GTX100536

GTX100536 IHC-P Image

Immunohistochemical analysis of paraffin-embedded human gastric , using MVP/LRP(GTX100536) antibody at 1:100 dilution.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min
REFERENCE
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REVIEW
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SDS
PBS.pdf
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 319
$ 169