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MYO6 antibody [MUD-19]

Anti-MYO6 antibody [MUD-19] used in Western Blot (WB). GTX11095

Cat. No. GTX11095

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 MUD-19

Isotype

 IgG1

Application

 WB, IP, ELISA, IHC

Reactivity

 Human, Mouse, Rat
Package
50 μl ($399)
See all MYO6 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 2 μg/ml
IP Assay dependent
ELISA Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

150 kDa. ( Note )

Positive Control

A431

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

~1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

synthetic peptide corresponding to amino acids 291-302 of human myosin VI.

Purification

Purified immunoglobulin

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

myosin VI , DFNA22 , DFNB37 , Myo6-007 , Myo6-008

Cellular Localization

Golgi apparatus,Nucleus

Background

Myosins belong to a superfamily of actin based motor proteins comprising at least 15 or more classes. There are two main groups of myosins: the conventional (class II) and the unconventional myosins. Myosin VI is a relatively abundant widespread unconventional myosin composed of an N-terminal motor domain, a light chain binding neck region, a coil-coiled region, and a highly conserved C-terminal domain. At the _x0018_converter_x0019_ region between the catalytic head and the neck region of myosin VI, there is a characteristic linker of approximately 50 amino acids. Native myosin VI is apparently a two-headed dimer of the heavy chains with each heavy chain bound to calmodulin light chain. Myosin VI is a unique _x0018_reverse_x0019_ actin motor in vitro i.e. to display motility towards the pointed (minus) ends of actin filaments, a direction opposite to all other currently known myosins.

Database

Research Area

DATA IMAGES

Anti-MYO6 antibody [MUD-19] used in Western Blot (WB). GTX11095

GTX11095 WB Image

WB analysis of various tissue lysates using GTX11095 MYO6 antibody [MUD-19].
Dilution : 0.5 μg/mL
Lane 1: A431
Lane 2: MCF-7
Lane 3: MDA-MB-231

REFERENCE

Application Reference

Hennlein L et al. J Cell Biol 2023; 222 (3) Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399