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Mast cell chymase antibody [CC1]

Cat. No. GTX75583

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 CC1

Isotype

 IgG1

Application

 WB, IHC-P, IHC-Fr, ELISA

Reactivity

 Human
Package
20 μg ($169)
See all Mast cell chymase products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-P 1/500-1/1,000
IHC-Fr Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

27 kDa. ( Note )

Positive Control

Skin

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified human skin chymase.

Purification

Protein A purified
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_376903

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

chymase 1 , CYH , MCT1 , chymase

Cellular Localization

Secreted

Background

This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015]

Database

Research Area

REFERENCE

Clone Reference

Stokes et al. 0 2015;:43127 METHODS AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF CARDIAC HYPERTROPHY.
Buckley CL et al. Channels (Austin) 2011; 5 (4):367-74 Mice lacking functional TRPV1 are protected from pressure overload cardiac hypertrophy.
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 169