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Matriptase / ST14 antibody [M24]

Anti-Matriptase / ST14 antibody [M24] used in Western Blot (WB). GTX02803

Cat. No. GTX02803

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 M24

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, IP

Reactivity

 Human
Package
100 μl ($399)
See all Matriptase / ST14 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1-5 μg/ml
ICC/IF Assay dependent
IHC-P Assay dependent
IP Assay dependent

Note :

WB
For the best detection sensitivity, the samples should be treated under non-boiled and non-reducing conditions.
Not tested in other applications.

Calculated MW

95 kDa. ( Note )

Positive Control

MCF-7

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human native protein

Purification

Purified by protein A

Purity

>90% determined by SDS-PAGE

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

suppression of tumorigenicity 14 , ARCI11 , HAI , MT-SP1 , MTSP1 , PRSS14 , SNC19 , TADG15 , TMPRSS14

Cellular Localization

Membrane

Background

The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Matriptase / ST14 antibody [M24] used in Western Blot (WB). GTX02803

GTX02803 WB Image

Whole cell extract (30 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Matriptase / ST14 antibody [M24] (GTX02803) diluted at 1:1000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody, and the signal was developed with Trident femto Western HRP Substrate.

REFERENCE

Clone Reference

Eric Camerer et al. 2010; Local protease signaling contributes to neural tube closure in the mouse embryo
Application : WB
Reactivity : Human
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Package List Price ($)
$ 399