GeneTex
United States (US)

Melan A antibody [MLANA/1409R]

GTX34831_20170712_IHC-P_18121410_895.jpg

Cat No. GTX34831

Host Rabbit
Clonality Monoclonal
Clone Name MLANA/1409R
Isotype IgG
Application IHC-P
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

IHC-P:0.5-1ug/ml for 30 minutes at RT.

Calculated MW

13 kDa. ( Note )

Specificity/Sensitivity

This antibody recognizes a protein doublet of 20-22kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. This MAb labels melanomas and other tumors showing melanocytic differentiation. It is also a useful positive-marker for angiomyolipomas. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant human full-length MLANA protein

Purification

Ab purified by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Melan-A,Mart-1,Mart1,Mlana

Database

Research Area

DATA IMAGES
GTX34831_20170712_IHC-P_18121410_895.jpg

GTX34831 IHC-P Image

Formalin-fixed, paraffin-embedded Human Melanoma stained with MART-1 Recombinant Rabbit Monoclonal Antibody (MLANA/1409R).

Package List Price ($)
$ 379