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Melanoma associated antigen antibody [HMB45]

Anti-Melanoma associated antigen antibody [HMB45] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX71957

Cat. No. GTX71957

Reference 3

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 HMB45

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human
Package
500 μl ($399)
See all Melanoma products

APPLICATION

Application Note

For IF: Use at an assay dependent dilution. For IHC-P: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.

PROPERTIES

Form

Liquid

Buffer

PBS pH7.4, 0.2% BSA

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Extract of pigmented melanoma metastases from lymph nodes.

Purification

Protein A affinity purified

Conjugation

Unconjugated

RRID

AB_383291

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Cellular Localization

Cytoplasmic

Background

This antibody reacts with an antigen present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells.This antibody reacts with melanomas and tumors showing melanoma/melanocytic differentiation. It reacts with junctional and blue nevus cells. Non-melanocytic cells do not react with this antibody.

Research Area

DATA IMAGES

Anti-Melanoma associated antigen antibody [HMB45] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX71957

GTX71957 ICC/IF Image

The data was published in the journal PLoS One in 2014. PMID: 25170965

REFERENCE

Application Reference

Bin BH et al. PLoS One 2014; 9 (8) : e105965 Hyperosmotic stress reduces melanin production by altering melanosome formation.
Application : WB
Reactivity : Human

Clone Reference

Yang CF et al. Am J Hum Genet 2018; 102 (2):219-232 Loss of GPNMB Causes Autosomal-Recessive Amyloidosis Cutis Dyschromica in Humans.
Lee E et al. Br J Dermatol 2016; ITAC induces the melanocytic migration and hypopigmentation through destabilizing p53 via HDAC5: A possible role of ITAC in pigment-related disorders.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399