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Mesothelin antibody [5B2]

Anti-Mesothelin antibody [5B2] used in IHC (Paraffin sections) (IHC-P). GTX01948

Cat. No. GTX01948

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 5B2

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($519)
See all Mesothelin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:40

Note :

IHC-P
The recommended fixative is 10% neutral-buffered formalin for paraffin-embedded tissue sections. Heat Induced Epitope Retreival (HIER) was performed in Epitope Retreival Solution pH6.
Not tested in other applications.

Calculated MW

69 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

Recombinant prokaryotic fusion protein corresponding to approximately 100 amino acids which are present in the membrane-bound form of the mesothelin molecule.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

mesothelin , MPF , SMRP

Cellular Localization

Golgi apparatus

Background

This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Database

Research Area

DATA IMAGES

Anti-Mesothelin antibody [5B2] used in IHC (Paraffin sections) (IHC-P). GTX01948

GTX01948 IHC-P Image

IHC-P analysis of human mesothelioma tissue using GTX01948 Mesothelin antibody [5B2]. Note intense membrane staining of tumor cells.

REFERENCE

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REVIEW

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Package List Price ($)
$ 519