GeneTex
United States (US)

Mineralocorticoid Receptor antibody

Cat No. GTX37373

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P, ELISA
Reactivity Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
IHC-P Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

107 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

0.01M TBS pH7.4, 0.5% BSA, 0.015% ProClin™ 300, 25% glycerol

Concentration

0.5mg/ml

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide derived between 611-690 amino acids of human MR

Purification

Protein A purified

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

MCR,MLR,MR,NR3C2VIT

Cellular Localization

Cytoplasm,Endoplasmic reticulum membrane,Nucleus

Background

This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
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Database

Research Area