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Moesin antibody [MSN/492]

Anti-Moesin antibody [MSN/492] used in IHC (Paraffin sections) (IHC-P). GTX34848
Anti-Moesin antibody [MSN/492] used in IHC (Paraffin sections) (IHC-P). GTX34848
Anti-Moesin antibody [MSN/492] used in IHC (Paraffin sections) (IHC-P). GTX34848

Cat No. GTX34848

Host Mouse
Clonality Monoclonal
Clone Name MSN/492
Isotype IgG1
Application WB, ICC/IF, IHC-P
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.5-1ug/ml
ICC/IF 0.5-1ug/ml
IHC-P 0.5-1ug/ml for 30 minutes at RT

Note :

IHC-P
Boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes

Not tested in other applications.

Calculated MW

68 kDa. ( Note )

Specificity/Sensitivity

Recognizes 78kDa moesin protein. Moesin, a member of the talin-4.1 superfamily, is a linking protein of the sub-membranous actin cytoskeleton. It is expressed in variable amounts in cells of different phenotypes such as macrophages, lymphocytes, fibroblastic, endothelial, epithelial, and neuronal cell lines but not in blood cells. The ERM proteins, ezrin, radixin, and moesin are involved in a variety of cellular functions, such as cell adhesion, migration, and the organization of cell surface structures, and are highly homologous, both in protein sequence and in functional activity, with merlin/schwannomin, a neurofibromatosis-2-associated tumor-suppressor protein. Cell lines of epithelial and mesothelial origin contain both moesin and radixin whereas cells of endothelial and lymphoid origin express moesin.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant full-length human Moesin protein

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Moesin,Hel70,Imd50,Msn

Background

Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
Anti-Moesin antibody [MSN/492] used in IHC (Paraffin sections) (IHC-P). GTX34848

GTX34848 IHC-P Image

Formalin-fixed, paraffin-embedded human Melanoma stained with Moesin Monoclonal Antibody (MSN/492)

Anti-Moesin antibody [MSN/492] used in IHC (Paraffin sections) (IHC-P). GTX34848

GTX34848 IHC-P Image

Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with Moesin Monoclonal Antibody (MSN/492)

Anti-Moesin antibody [MSN/492] used in IHC (Paraffin sections) (IHC-P). GTX34848

GTX34848 IHC-P Image

Formalin-fixed, paraffin-embedded human Placenta stained with Moesin Monoclonal Antibody (MSN/492)

Package List Price ($)
$ 329