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Mouse Anti-Human IgM antibody [8H6]

Mouse Anti-Human IgM antibody [8H6]. GTX01856

Cat No. GTX01856

Host

Mouse

Clonality

Monoclonal

Clone Name

8H6

Isotype

IgG2a

Application

IHC-P

Reactivity

Human
Package
500 μl ($349)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 1:800

Note :

IHC-P
The recommended fixative is 10% neutral-buffered formalin for paraffin-embedded tissue sections. Heat Induced Epitope Retreival (HIER) was performed in Epitope Retrieval Solution pH 9.

Not tested in other applications.

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

>41 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Prokaryotic recombinant protein corresponding to a portion of the N terminus of the heavy chain constant region.

Target Isotype

IgM

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

immunoglobulin heavy constant mu , AGM1 , MU , VH

Background

Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).[supplied by OMIM, Aug 2010]

Database

  • Gene ID: 3507 IGHM

Research Area

DATA IMAGES

Mouse Anti-Human IgM antibody [8H6]. GTX01856

GTX01856 IHC-P Image

IHC-P analysis of human tonsil tissue using GTX01856 Human IgM antibody [8H6]. Note intense staining of plasma cells, weaker staining of follicular dendritic cell network and some B cells.

REFERENCE

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REVIEW

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Package List Price ($)
$ 349