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Mouse ICAM1 / CD54 protein, mutant mouse IgG2a Fc tag (active)

Cat No. GTX65788-pro

Application

Functional Assay

Species

Mouse
Package
50 μg ($289)
PRODUCT

Summary

Non-lytic: Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).

APPLICATION

Application Note

Shows the biological function of the CD54 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.

PROPERTIES

Form

Lyophilized powder

Buffer

Lyophilized from 0.2μm-filtered PBS. Reconstitute with 0.2μm-filtered PBS to 100μg/ml.

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Aliquot and avoid freeze-thaw cycles.

Region/Sequence

The extracellular domain of mouse CD54 [ICAM-1] (a.a. 28-485) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a.

Expression System

CHO cells

Purity

≥ 98% by SDS-PAGE.

Endotoxin

< 0.06 EU/μg

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

intercellular adhesion molecule 1 , CD54 , Icam-1 , Ly-47 , MALA-2

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf