GeneTex
  • Country / Location Selection

United States (US)

Mouse beta Catenin protein, GST and His tag

Mouse beta Catenin protein, GST and His tag. GTX01245-pro

Cat No. GTX01245-pro

Species

Mouse
Package
20 μg ($329),
10 μg ($249)

APPLICATION

Calculated MW

85 kDa. ( Note )

Observed MW

115 kDa.

PROPERTIES

Form

Lyophilized powder

Buffer

Batch dependent (please contact us for details)

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Avoid freeze-thaw cycles.

Region/Sequence

N-terminal GST and poly His tagged; Met1-Leu781 of Mouse beta Catenin protein (Q02248)

Expression System

Baculovirus-Insect cells

Purity

> 90% by SDS-PAGE.

Endotoxin

< 1.0 EU/μg (determined by LAL method)

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

catenin (cadherin associated protein), beta 1 , Bfc , Catnb , Mesc

Cellular Localization

Cytoplasm , Nucleus , Cytoplasm, cytoskeleton , Cell junction , Cell membrane , Cell junction, synapse

Background

This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Another key function of this protein is to mediate the canonical Wnt signaling pathway and regulate gene transcription. Without Wnt signal, cytoplasmic beta-catenin that is not associated with the cadherin complex is quickly phosphorylated at the N-terminal Ser/Thr residues by the so called degradation complex containing axin, adenomatous polyposis coli (APC), casein kinase I, and GSK3B, then ubiquitylated by beta-TrCP, and degraded by the proteasome. However, in the presence of Wnt signal, the degradation complex is disrupted and the stabilized cytoplasmic beta-catenin translocates into the nucleus, where it binds various transcription factors and, together with these factors, regulates the transcription of many downstream genes. Mutations of this gene have been linked with various types of tumors. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2009]

Database

Research Area

DATA IMAGES

Mouse beta Catenin protein, GST and His tag. GTX01245-pro

GTX01245-pro Image

SDS-PAGE of 5 μg GTX01245-pro Mouse beta Catenin protein, GST and His tag.

REFERENCE

There are currently no references for Mouse beta Catenin protein, GST and His tag (GTX01245-pro). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for Mouse beta Catenin protein, GST and His tag (GTX01245-pro). Be the first to share your experience with this product.
Package List Price ($)
$ 329
$ 249