Mre11 antibody [12D7]
Cat. No. GTX70212
Cat. No. GTX70212
This Mre11 antibody [12D7] (GTX70212) is a mouse monoclonal antibody validated for detection of Mre11 by WB, ICC/IF, IP, ELISA, Functional Assay, and PLA. Reactivity has been shown in Human. This product is cited in 194 published studies. Knockout/knockdown validation supports antibody specificity.
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HostMouse
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ClonalityMonoclonal
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Clone Name12D7
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IsotypeIgG1
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ApplicationsWB ICC/IF IP ELISA Functional Assay PLA
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ReactivityHuman
Summary
MRE11 antibody recognizes MRE11 protein, an enzyme with a predicted molecular weight of ~81 kDa. MRE11 forms the core of the MRN (MRE11-RAD50-NBS1) complex, one of the first components of the DNA damage response (DDR) to DNA double-strand breaks where it recruits other signaling factors required for repair. MRE11 has both exonuclease and endonuclease activities, and is responsible for the DNA binding of the complex.