GeneTex
United States (US)

Mucin 5AC antibody [CLH2]

GTX34869_20170712_IHC-P_18121410_672.jpg

Cat No. GTX34869

Host Mouse
Clonality Monoclonal
Clone Name CLH2
Isotype IgG1
Application IHC-P
Reactivity Human
APPLICATION

Application Note

IHC-P:1-2ug/ml for 30 minutes at RT.

Specificity/Sensitivity

Mucin 5AC glycoprotein (MUC5AC) is a HMW glycoprotein belonging to the superfamily of mucins. Mucins are produced by epithelial cells and can be divided into two families; secretory mucins and membrane bound mucins. MUC5AC is a mucus-forming, secreted mucin that is found in normal gastric and tracheo-bronchial mucosa, but absent from normal colon. MUC5AC expression is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

A synthetic peptide of human MUC5AC tandem repeat

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Mucin 5Ac, Oligomeric Mucus/Gel-Forming,Muc5,Tbm,Leb,Mucin,Muc5Ac
DATA IMAGES
GTX34869_20170712_IHC-P_18121410_672.jpg

GTX34869 IHC-P Image

Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with MUC5AC Mouse Monoclonal Antibody (CLH2).Courtesy of Dr. Leonor David, IPATIMUP and Medical Faculty, University of Porto, Portugal.

Package List Price ($)
$ 329