GeneTex

  • Country / Location Selection

United States (US)

Munc 13-4 antibody [C3], C-term

Anti-Munc 13-4 antibody [C3], C-term used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX108105
Anti-Munc 13-4 antibody [C3], C-term used in Western Blot (WB). GTX108105
Anti-Munc 13-4 antibody [C3], C-term used in IHC (Paraffin sections) (IHC-P). GTX108105

Cat. No. GTX108105

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human
Package
100 μl ($399),
25 μl ($169)
See all Munc 13-4 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
ICC/IF 1:100-1:1000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

123 kDa. ( Note )

Positive Control

Jurkat , K562

PROPERTIES

Form

Liquid

Buffer

0.1M Tris, 0.1M Glycine, 10% Glycerol

Preservative

0.01% Thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Munc 13-4. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_1241083

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

unc-13 homolog D , FHL3 , HLH3 , HPLH3 , Munc13-4

Cellular Localization

Cytoplasm , Membrane; Peripheral membrane protein

Background

This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-Munc 13-4 antibody [C3], C-term used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX108105

GTX108105 ICC/IF Image

Immunofluorescence analysis of methanol-fixed HeLa, using Munc 13-4(GTX108105) antibody at 1:500 dilution.

Anti-Munc 13-4 antibody [C3], C-term used in Western Blot (WB). GTX108105

GTX108105 WB Image

Sample (30 ug of whole cell lysate)
A: Jurkat
B: K562
5% SDS PAGE
GTX108105 diluted at 1:1000

Anti-Munc 13-4 antibody [C3], C-term used in IHC (Paraffin sections) (IHC-P). GTX108105

GTX108105 IHC-P Image

Immunohistochemical analysis of paraffin-embedded human stomach, using UNC13D(GTX108105) antibody at 1:100 dilution.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

REFERENCE

Application Reference

Bhat A et al. Hepatol Commun 2020; 4 (1) : 50-65 Hyperoxidized Albumin Modulates Platelets and Promotes Inflammation Through CD36 Receptor in Severe Alcoholic Hepatitis.
Submit a Reference

REVIEW

There are currently no reviews for Munc 13-4 antibody [C3], C-term (GTX108105). Be the first to share your experience with this product.
Submit a Review
SDS
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 399
$ 169