APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1-2 μg/ml |
|
Note :
IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris buffer with 1mM EDTA (pH 9.0) for 45 min at 95ºC followed by cooling at RT for 20 minutes.
|
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
10mM PBS, 0.05% BSA
Preservative
0.05% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Concentration
200 μg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant full-length human MYH11 protein
Purification
Protein A/G purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
myosin heavy chain 11 , AAT4 , FAA4 , SMHC , SMMHC
Background
The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
![Anti-Myosin Heavy Chain 11 antibody [MYH11/2303R] used in IHC (Paraffin sections) (IHC-P). GTX02683](/templates/default/js/lightbox/images/loading.gif "Anti-Myosin Heavy Chain 11 antibody [MYH11/2303R] used in IHC (Paraffin sections) (IHC-P). GTX02683")
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GTX02683 IHC-P Image
IHC-P analysis of human breast carcinoma section using GTX02683 Myosin Heavy Chain 11 antibody [MYH11/2303R].
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GTX02683 IHC-P Image
IHC-P analysis of human breast carcinoma section using GTX02683 Myosin Heavy Chain 11 antibody [MYH11/2303R].
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GTX02683 IHC-P Image
IHC-P analysis of human prostate carcinoma section using GTX02683 Myosin Heavy Chain 11 antibody [MYH11/2303R].
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REFERENCE
There are currently no references for Myosin Heavy Chain 11 antibody [MYH11/2303R] (GTX02683). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Myosin Heavy Chain 11 antibody [MYH11/2303R] (GTX02683). Be the first to share your experience with this product.
![Anti-Myosin Heavy Chain 11 antibody [MYH11/2303R] used in IHC (Paraffin sections) (IHC-P). GTX02683](/upload/website/prouct_img/small/GTX02683/GTX02683_20210319_IHC-P_w_23053122_607.webp "Anti-Myosin Heavy Chain 11 antibody [MYH11/2303R] used in IHC (Paraffin sections) (IHC-P). GTX02683")
![Anti-Myosin Heavy Chain 11 antibody [MYH11/2303R] used in IHC (Paraffin sections) (IHC-P). GTX02683](/upload/website/prouct_img/small/GTX02683/GTX02683_20210319_IHC-P_1_w_23053122_503.webp "Anti-Myosin Heavy Chain 11 antibody [MYH11/2303R] used in IHC (Paraffin sections) (IHC-P). GTX02683")
![Anti-Myosin Heavy Chain 11 antibody [MYH11/2303R] used in IHC (Paraffin sections) (IHC-P). GTX02683](/upload/website/prouct_img/small/GTX02683/GTX02683_20210319_IHC-P_2_w_23053122_490.webp "Anti-Myosin Heavy Chain 11 antibody [MYH11/2303R] used in IHC (Paraffin sections) (IHC-P). GTX02683")
![Anti-Myosin Heavy Chain 11 antibody [MYH11/2303R] used in IHC (Paraffin sections) (IHC-P). GTX02683](/upload/website/prouct_img/normal/GTX02683/GTX02683_20210319_IHC-P_w_23053122_607.webp "Anti-Myosin Heavy Chain 11 antibody [MYH11/2303R] used in IHC (Paraffin sections) (IHC-P). GTX02683")
![Anti-Myosin Heavy Chain 11 antibody [MYH11/2303R] used in IHC (Paraffin sections) (IHC-P). GTX02683](/upload/website/prouct_img/normal/GTX02683/GTX02683_20210319_IHC-P_1_w_23053122_503.webp "Anti-Myosin Heavy Chain 11 antibody [MYH11/2303R] used in IHC (Paraffin sections) (IHC-P). GTX02683")
![Anti-Myosin Heavy Chain 11 antibody [MYH11/2303R] used in IHC (Paraffin sections) (IHC-P). GTX02683](/upload/website/prouct_img/normal/GTX02683/GTX02683_20210319_IHC-P_2_w_23053122_490.webp "Anti-Myosin Heavy Chain 11 antibody [MYH11/2303R] used in IHC (Paraffin sections) (IHC-P). GTX02683")