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Myotilin antibody [RSO34]

Anti-Myotilin antibody [RSO34] used in IHC (Paraffin sections) (IHC-P). GTX01881

Cat. No. GTX01881

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 RSO34

Isotype

 IgG1

Application

 IHC-P, IHC-Fr

Reactivity

 Human
Package
500 μl ($659)
See all Myotilin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:40–1:80
IHC-Fr 1:20

Note :

IHC-P
High temperature antigen unmasking technique. Standard ABC technique.

IHC-Fr
Standard ABC technique. Acetone fixation recommended.
Not tested in other applications.

Calculated MW

55 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Prokaryotic recombinant protein corresponding to a C-terminal region of 266 amino acids of the human myotilin molecule.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

myotilin , LGMD1 , LGMD1A , MFM3 , TTID , TTOD

Cellular Localization

Cytoplasm, cytoskeleton

Background

This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[provided by RefSeq, Oct 2008]

Database

Research Area

DATA IMAGES

Anti-Myotilin antibody [RSO34] used in IHC (Paraffin sections) (IHC-P). GTX01881

GTX01881 IHC-P Image

IHC-P analysis of human skeletal muscle tissue using GTX01881 Myotilin antibody [RSO34]. Note sarcoplasmic staining of normal muscle fibers (A) and presence of protein aggregates (B).

REFERENCE

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REVIEW

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Package List Price ($)
$ 659