N-Cadherin antibody recognizes N-cadherin protein, a calcium-dependent cell adhesion protein (predicted molecular weight of 100 kDa) encoded by the CDH2 gene. N-cadherin is involved in multiple processes, including neuron development and epithelial-mesenchymal transition (EMT). Due to the prominent role of EMT in cancer progression and metastasis, antibodies targeting either N-cadherin or E-cadherin are frequently used together to study the EMT process: the upregulation of N-cadherin followed by the downregulation of E-cadherin.
*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
293T , NT2D1 , SK-N-SH , mouse brain , rat brain , *A549
Bovine, Dog, Chicken(>80% identity)
1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
0.15 mg/ml (Please refer to the vial label for the specific concentration.)
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human N-Cadherin. The exact sequence is proprietary.
Purified by antigen-affinity chromatography.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
cadherin 2 , CD325 , CDHN , CDw325 , NCAD
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq]