APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500-1:2000 |
| 1:50-1:200 |
| 1:50-1:200 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS pH 7.3, 50% glycerol
Preservative
0.05% proclin300
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1370-1473 of human NLRP1 (NP_127497.1)
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
NLR family pyrin domain containing 1 , AIADK , CARD7 , CIDED , CLR17.1 , DEFCAP , DEFCAP-L/S , MSPC , NAC , NALP1 , PP1044 , SLEV1 , VAMAS1
Cellular Localization
Cytoplasm, cytosol , Cytoplasm , Nucleus
Background
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX04254 ICC/IF Image
ICC/IF analysis of PC-12 cells using GTX04254 NALP1 antibody.
Dilution : 1:50
Blue : DAPI
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GTX04254 WB Image
WB analysis of K562 cell lysates using GTX04254 NALP1 antibody.
Loading : 25 μg
Dilution : 1:1000
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GTX04254 ICC/IF Image
ICC/IF analysis of K562 cells using GTX04254 NALP1 antibody.
Dilution : 1:50
Blue : DAPI
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GTX04254 IHC-P Image
IHC-P analysis of human tonsil tissue using GTX04254 NALP1 antibody.
Antigen retrieval : 10 mM citrate buffer (pH 6)
Dilution : 1:50
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GTX04254 ICC/IF Image
ICC/IF analysis of SH-SY5Y cells using GTX04254 NALP1 antibody.
Dilution : 1:50
Blue : DAPI
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GTX04254 IHC-P Image
IHC-P analysis of human colon tissue using GTX04254 NALP1 antibody.
Antigen retrieval : 10 mM citrate buffer (pH 6)
Dilution : 1:50
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REFERENCE
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REVIEW
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