APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
1-4 μg/mL |
20 μg/mL |
Assay dependent |
10 μg/mL |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
NALP1 antibody was raised against a peptide corresponding to 13 amino acids near the carboxy terminus of human NALP1. The immunogen is located within the last 50 amino acids of NALP1.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
NLR family pyrin domain containing 1 , AIADK , CARD7 , CIDED , CLR17.1 , DEFCAP , DEFCAP-L/S , MSPC , NAC , NALP1 , PP1044 , SLEV1 , VAMAS1
Cellular Localization
Cytoplasm, cytosol , Cytoplasm , Nucleus
Background
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX04532 WB Image
WB analysis of U937 whole cell lysate using GTX04532 NALP1 antibody. Dilution : Lane 1 : 1 μg/mL Lane 2 : 2 μg/mL Lane 3 : 4 μg/mL
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GTX04532 ICC/IF Image
ICC/IF analysis of K562 cells using GTX04532 NALP1 antibody. Dilution : 20 μg/mL
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GTX04532 IHC-P (cell pellet) Image
IHC-P (cell pellet) analysis of K562 cells using GTX04532 NALP1 antibody. Dilution : 10 μg/mL
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REFERENCE
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REVIEW
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