GeneTex
United States (US)

NCAM antibody [NCAM1/795]

GTX34894_20170712_IHC-P_18121410_841.jpg
GTX34894_20170725_IHC-P_2_18121410_997.jpg
GTX34894_20170712_WB_18121410_536.jpg
GTX34894_20170712_IHC-P_1_18121410_368.jpg

Cat No. GTX34894

Host Mouse
Clonality Monoclonal
Clone Name NCAM1/795
Isotype IgG1
Application WB, IHC-P
Reactivity Human
APPLICATION

Application Note

IHC-P:0.5-1ug/ml for 30 minutes at RT, WB:0.5-1ug/ml.

Calculated MW

95 kDa. ( Note )

Specificity/Sensitivity

This MAb reacts with an extracellular domain (close to transmembrane) of CD56/NCAM. Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant human NCAM1 protein

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Neural Cell Adhesion Molecule 1,Cd56,Msk39,Ncam,Ncam1

Background

This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

Database

Research Area

DATA IMAGES
GTX34894_20170712_IHC-P_18121410_841.jpg

GTX34894 IHC-P Image

Formalin-fixed, paraffin-embedded human Brain Tumor stained with CD56 Monoclonal Antibody (NCAM1/795)

GTX34894_20170725_IHC-P_2_18121410_997.jpg

GTX34894 IHC-P Image

Formalin-fixed, paraffin-embedded human pancreas stained with CD56 Monoclonal Antibody (NCAM1/795)

GTX34894_20170712_WB_18121410_536.jpg

GTX34894 WB Image

Western Blot Analysis of HCT116 Cell Lysate using CD56 Monoclonal Antibody (NCAM1/795)

GTX34894_20170712_IHC-P_1_18121410_368.jpg

GTX34894 IHC-P Image

Formalin-fixed, paraffin-embedded human Lung Carcinomastained with CD56 Monoclonal Antibody (NCAM1/795)

Package List Price ($)
$ 329