NFkB p100 (phospho Ser869) antibody

Cat. No. GTX79001

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC-P
Reactivity	Human
Package	100 μg ($399)

See all NFkB p100 products

Datasheet

View product citations for antibody GTX79001 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1:500 - 1:1000
IHC-P	1:50 - 1:100

Not tested in other applications.

Calculated MW

97 kDa. ( Note )

Predict Reactivity

Mouse, Rat(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized phosphopeptide derived from human NF-κB around the phosphorylation site of serine 869 (Y-G-Sp-Q-S).

Purification

Purified by sequential chromatography on phospho- and non-phospho-peptide affinity columns.
From serum

Conjugation

Unconjugated

RRID

AB_11173529

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CVID10,H2TF1,LYT10,NFKB2,NFkB2,nuclear factor kappa B subunit 2,p100,p49/p100,p52,NFkB p100 / p52,NFkB p100,NF-κb p100,NF-κb p52

Cellular Localization

Nucleus,Cytoplasm

Background

This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Database

Gene ID: 4791 NFKB2
UniProt: Q00653 NFKB2

Research Area

DATA IMAGES

GTX79001 WB Image

WB analysis of MDA-MB-435 cells untreated or treated with TNF-α (20ng/ml, 5min) lysates using GTX79001 NFkB p100 (phospho Ser869) antibody.

GTX79001 IHC-P Image

IHC-P analysis of human breast carcinoma tissue using GTX79001 NFkB p100 (phospho Ser869) antibody.

REFERENCE

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REVIEW

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Package

List Price ($)

100 μg

$ 399

Qty