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NKCC2 antibody

Anti-NKCC2 antibody used in Western Blot (WB). GTX41968

Cat. No. GTX41968

Reference 2

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
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APPLICATION

Application Note

We recommend a working dilution of 1:1000 (WB).

Calculated MW

160 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Rabbit immunoglobulin, 50% Glycerol

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Immunogen

AA109 to 129 of the rat sequence

Purification

Affinity purified

Conjugation

Unconjugated

RRID

AB_10734243

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Solute Carrier Family 12 Member 1 , Bsc1 , Nkcc2 , Slc12A1

Background

NKCC2, a kidney-specific member of the cation chloride co-transporter family SLC12, facilitates transport of sodium, potassium, and chloride ions from the lumen of the renal thick ascending limb into the cell. Transport of sodium dilutes the luminal fluid, decreasing its osmolality creating an osmotic driving force for water reabsorption in the connecting tubule and cortical collecting duct under the influence of the hormone vasopressin. NKCC2 is found on the apical surface of the thick ascending limb of the loop of Henle and is blocked by loop diuretics such as furosemide.

Research Area

DATA IMAGES

Anti-NKCC2 antibody used in Western Blot (WB). GTX41968

GTX41968 WB Image

Western blot analysis of NKCC2 in rat kidney tissue using a 1:1000 dilution of GTX41968.
OM:Outer Medulla

REFERENCE

Application Reference

Cooper DL et al. PLoS One 2014; 9 (2) : e89087 exacerbation of *-induced renal injury by concomitant administration of * in rats.
Application : WB
Reactivity : Rat
Toka HR et al. J Am Soc Nephrol 2012; 23 (11) : 1879-90 Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria.
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SDS
Glycerol.pdf
Package List Price ($)
$ 399