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NKX2.1 antibody [SPT24]

Anti-NKX2.1 antibody [SPT24] used in IHC (Paraffin sections) (IHC-P). GTX01952

Cat. No. GTX01952

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 SPT24

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($589)
See all NKX2.1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:200

Note :

IHC-P
The recommended fixative is 10% neutral-buffered formalin for paraffin-embedded tissue sections. Heat Induced Epitope Retreival (HIER) was performed in Epitope Retreival Solution pH6.
Not tested in other applications.

Calculated MW

39 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

Prokaryotic recombinant protein corresponding to a 123 amino acid fragment of the N-terminal region of the TTF-1 molecule.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

NK2 homeobox 1 , BCH , BHC , NK-2 , NKX2.1 , NKX2A , NMTC1 , T/EBP , TEBP , TITF1 , TTF-1 , TTF1

Cellular Localization

Nucleus

Background

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014]

Database

Research Area

DATA IMAGES

Anti-NKX2.1 antibody [SPT24] used in IHC (Paraffin sections) (IHC-P). GTX01952

GTX01952 IHC-P Image

IHC-P analysis of human thyroid tissue using GTX01952 NKX2.1 antibody [SPT24]. Note nuclear staining of thyroid epithelial cells.

REFERENCE

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REVIEW

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Package List Price ($)
$ 589