APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
1 μg/mL |
2.5 μg/mL |
Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
K-562 Cell Slide(GTX25535) , K562 Cell Lysate(GTX27911)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
NALP13 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human NALP13.The immunogen is located within amino acids 150 - 200 of NALP13.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
NLR family pyrin domain containing 13 , CLR19.7 , NALP13 , NOD14 , PAN13
Background
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP13, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]
Database
Research Area
DATA IMAGES
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GTX31990 ICC/IF Image
ICC/IF analysis of K562 cells using GTX31990 NLRP13 antibody. Working concentration : 20 μg/ml
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GTX31990 ICC/IF Image
ICC/IF analysis of K562 cells using GTX31990 NLRP13 antibody. Working concentration : 2.5 μg/ml
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GTX31990 WB Image
WB analysis of K562 cell lysate using GTX31990 NLRP13 antibody. Working concentration : 1 μg/ml
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REFERENCE
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REVIEW
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