*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
GTX84019 is specific for amino acids 2300-2556 of human NOTCH1
PBS pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
0.20mg/ml(Please refer to the vial label for the specific concentration.)
Recombinant protein expressed in E.coli corresponding to amino acids 2300-2556 of human NOTCH1
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
N1 Antibody , Mis6 Antibody , Tan1 Antibody , notch 1 Antibody , 9930111A19Rik Antibody , lin-12 Antibody
Cell membrane; Single-pass type I membrane protein , Notch 1 intracellular domain: Nucleus (By similarity)
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia.