APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500~1:1000 |
| 1:50~1:100 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS (without Mg²⁺ and Ca²⁺) pH7.4, 150mM NaCl, 50% Glycerol
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
The antiserum was produced against synthesized peptide derived from human NOTCH1 (1735-1784).
Purification
Purified by antigen-affinity chromatography
From serum
Conjugation
Unconjugated
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
AOS5 , AOVD1 , NOTCH1 , TAN1 , hN1 , notch 1 , Notch 1
Cellular Localization
Cell membrane,Nucleus
Background
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX86924 WB Image
WB analysis of KB cell lysates using GTX86924 NOTCH1 (cleaved Val1754) antibody.
Dilution : 1:500
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GTX86924 IHC-P Image
IHC-P analysis of human brain tissue using GTX86924 NOTCH1 (cleaved Val1754) antibody. The picture on the right is blocked with the synthesized peptide.
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REFERENCE
There are currently no references for NOTCH1 (cleaved Val1754) antibody (GTX86924). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for NOTCH1 (cleaved Val1754) antibody (GTX86924). Be the first to share your experience with this product.
