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NOTCH3 antibody

Anti-NOTCH3 antibody used in Western Blot (WB). GTX33362

Cat. No. GTX33362

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human
Package
100 μl ($399)
See all NOTCH3 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:200 - 1:1000
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

244 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide of human NOTCH3

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_2887710

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

notch receptor 3 , CADASIL , CADASIL1 , CASIL , IMF2 , LMNS

Cellular Localization

Cell membrane

Background

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-NOTCH3 antibody used in Western Blot (WB). GTX33362

GTX33362 WB Image

WB analysis of 293T cell lysate using GTX33362 NOTCH3 antibody. The signal was developed with ECL plus-Enhanced.
Dilution : 1:400
Loading : 25μg per lane

REFERENCE

Application Reference

Kim MJ et al. Journal of Cancer 2017; 8 (16) : 3331-3342 Correlation of ALDH1 and Notch3 Expression: Clinical implication in Ovarian Carcinomas.
Application : IHC-P
Reactivity : Human
Submit a Reference

REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399