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NOX2 / gp91phox antibody [NL7]

Cat. No. GTX80329

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 NL7

Isotype

 IgG1

Application

 WB

Reactivity

 Human
Package
50 μl ($319)
See all NOX2 / gp91phox products

APPLICATION

Application Note

Recommended Starting Dilutions:
For WB: Use at 1:1000
Optimal dilutions should be determined experimentally by the researcher.

Calculated MW

65 kDa. ( Note )

Product Note

Human NOX2/gp91phox – 498-EKDVITGRKQ-507

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Partially purified human neutrophil flavocytochrome b (heparin Ultrogel/lectin affinity purification in octyl glucoside)

Purification

Protein G

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

cytochrome b-245 beta chain , AMCBX2 , CGD , GP91-1 , GP91-PHOX , GP91PHOX , IMD34 , NOX2 , p91-PHOX

Cellular Localization

Cell membrane; Multi-pass membrane protein

Background

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 319