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NOX2 / gp91phox antibody

Anti-NOX2 / gp91phox antibody used in IHC (Paraffin sections) (IHC-P). GTX00785
Anti-NOX2 / gp91phox antibody used in Western Blot (WB). GTX00785

Cat. No. GTX00785

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all NOX2 / gp91phox products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

65 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 283-570 of human NOX2 / gp91phox (NP_000388.2).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

AMCBX2 , CGD , CYBB , GP911 , GP91PHOX , IMD34 , NOX2 , cytochrome b245 beta chain , p91PHOX , gp91phox , cytochrome B245 heavy chain , gp91-phox , Cytochrome B245 beta , cytochrome b-245 beta chain

Cellular Localization

Cell membrane

Background

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-NOX2 / gp91phox antibody used in IHC (Paraffin sections) (IHC-P). GTX00785

GTX00785 IHC-P Image

IHC-P analysis of rat bone marrow tissue using GTX00785 NOX2 / gp91phox antibody.
Dilution : 1:200

Anti-NOX2 / gp91phox antibody used in Western Blot (WB). GTX00785

GTX00785 WB Image

WB analysis of various sample lysates using GTX00785 NOX2 / gp91phox antibody.
Dilution : 1:1000
Loading : 25μg per lane

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399