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NR0B2 antibody

Anti-NR0B2 antibody used in IHC (Paraffin sections) (IHC-P). GTX70897

Cat No. GTX70897

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

ICC/IF, IHC-P

Reactivity

Human, Mouse, Rabbit, Hamster, Monkey
Package
25 μg ($269)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF Assay dependent
IHC-P 4 μg/ml
Not tested in other applications.

Calculated MW

28 kDa. ( Note )

Predict Reactivity

Rat, Bovine, Dog, Pig, Bat, Elephant, Gibbon, Gorilla, Horse, Marmoset, Opossum, Panda(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic 16 amino acid peptide from ligand-binding domain of human NR0B2.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

nuclear receptor subfamily 0 group B member 2 , NR0B2 , SHP , SHP1

Cellular Localization

Nucleus,Cytoplasm

Background

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-NR0B2 antibody used in IHC (Paraffin sections) (IHC-P). GTX70897

GTX70897 IHC-P Image

IHC-P analysis of human liver, hepatocytes tissue using GTX70897 NR0B2 antibody.
Antigen retrieval : Heat-induced antigen retrieval

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf