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NRF2 antibody [N2C2], Internal

KO/KD Comparison Orthogonal Overexpression
Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322
Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322
Anti-NRF2 antibody [N2C2], Internal used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX103322
Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322
Anti-NRF2 antibody [N2C2], Internal used in IHC (Paraffin sections) (IHC-P). GTX103322
Anti-NRF2 antibody [N2C2], Internal used in ChIP assay (ChIP assay). GTX103322
Anti-NRF2 antibody [N2C2], Internal used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX103322
Anti-NRF2 antibody [N2C2], Internal used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX103322
Anti-NRF2 antibody [N2C2], Internal used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX103322
Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322
Anti-NRF2 antibody [N2C2], Internal used in Immunoprecipitation (IP). GTX103322
Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322
Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322
Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322
Anti-NRF2 antibody [N2C2], Internal used in IHC (Paraffin sections) (IHC-P). GTX103322
Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322
Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322
Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322
Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322
Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322

Cat. No. GTX103322

Reference 117
2

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, FACS, IP, ChIP assay

Reactivity

 Human, Mouse, Rat, Zebrafish, Alligator, Plant, Bird
Package
100 μl ($399),
25 μl ($169)
See all NRF2 products
PRODUCT

Summary

NRF2 antibody recognizes NRF2 protein, a basic leucine zipper region (bZip) transcription factor (predicted molecular weight of 68 kDa) that regulates expression of proteins with antioxidant and detoxification functions. NRF2 antibodies are commonly used to study oxidative stress, cell damage, metabolism, and immune response mechanisms, among others.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
ICC/IF 1:100-1:1000
IHC-P 1:100-1:1000
FACS Assay dependent
IP 1:100-1:500
ChIP assay Assay dependent
Not tested in other applications.

Calculated MW

68 kDa. ( Note )

Observed MW

110 kDa. The observed M.W. is based on the following publication. PMID: 22703241

Positive Control

3xFlag-human NFE2L2-transfected 293T , MDA-MB-231 nuclear extract , MDA-MB-231 nuclear extract (30uM tBHQ 4hr) , RAW264.7 (500 ng/ml LPS treatment for 6 hr)

Predict Reactivity

Bovine, Rhesus Monkey(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA, 20% Glycerol

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.31 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human NRF2. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_1950993

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

nuclear factor, erythroid 2 like 2 , HEBP1 , IMDDHH , NRF2

Cellular Localization

Cytoplasm , cytosol , Nucleus

Background

NFE2 (MIM 601490), NFE2L1 (MIM 163260), and NFE2L2 comprise a family of human genes encoding basic leucine zipper (bZIP) transcription factors. They share highly conserved regions that are distinct from other bZIP families, such as JUN (MIM 165160) and FOS (MIM 164810), although remaining regions have diverged considerably from each other (Chan et al., 1995 [PubMed 7868116]).[supplied by OMIM]

Database

Research Area

DATA IMAGES

Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322

GTX103322 WB Image

Comparison Orthogonal

Untreated (–) and treated (+) HepG2 whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membranes were blotted with NRF2 antibody [N2C2], Internal (GTX103322) diluted at 1:500 and competitor's antibody diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

*The competitor is not affiliated with GeneTex and does not endorse this product.

Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322

GTX103322 WB Image

Orthogonal

Untreated (–) and treated (+) MDA-MB-231 nuclear extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with NRF2 antibody [N2C2], Internal (GTX103322) diluted at 1:1000.

Anti-NRF2 antibody [N2C2], Internal used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX103322

GTX103322 ICC/IF Image

NRF2 antibody [N2C2], Internal detects NRF2 protein at cytoplasm and nucleus by immunofluorescent analysis.
Sample: NIH/3T3 cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: NRF2 protein stained by NRF2 antibody [N2C2], Internal (GTX103322) diluted at 1:500.
Blue: Hoechst 33342 staining.
Scale bar = 10 μm.

Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322

GTX103322 WB Image

Overexpression

NRF2 antibody detects NRF2 protein by western blot analysis. Non-transfected (-) and NRF2-transfected (+, including 3xFlag-tag) 293T whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with NRF2 antibody (GTX103322) diluted by 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-NRF2 antibody [N2C2], Internal used in IHC (Paraffin sections) (IHC-P). GTX103322

GTX103322 IHC-P Image

NRF2 antibody [N2C2], Internal detects NRF2 protein at cytoplasm and nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded human breast carcinoma.
NRF2 stained by NRF2 antibody [N2C2], Internal (GTX103322) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-NRF2 antibody [N2C2], Internal used in ChIP assay (ChIP assay). GTX103322

GTX103322 ChIP assay Image

ChIP was performed with HepG2 chromatin extract and 5 μg of either normal rabbit IgG or anti-NRF2 antibody. The precipitated DNA was detected by PCR with primer set targeting to GCLC gene locus.

Anti-NRF2 antibody [N2C2], Internal used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX103322

GTX103322 ICC/IF Image

NRF2 antibody [N2C2], Internal detects NRF2 protein at nucleus by immunofluorescent analysis.
Sample: Neuro2A cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: NRF2 stained by NRF2 antibody [N2C2], Internal (GTX103322) diluted at 1:1000.

Anti-NRF2 antibody [N2C2], Internal used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX103322

GTX103322 ICC/IF Image

Orthogonal

NRF2 antibody [N2C2], Internal detects NRF2 protein at nucleus by immunofluorescent analysis.
Sample: Mock and treated HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: NRF2 stained by NRF2 antibody [N2C2], Internal (GTX103322) diluted at 1:500.
Blue: Fluoroshield with DAPI (GTX30920).

Anti-NRF2 antibody [N2C2], Internal used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX103322

GTX103322 ICC/IF Image

NRF2 antibody [N2C2], Internal detects NRF2 protein at nucleus by immunofluorescent analysis.
Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: NRF2 stained by NRF2 antibody [N2C2], Internal (GTX103322) diluted at 1:1000.
Red: phalloidin, a cytoskeleton marker, diluted at 1:200.
Scale bar= 10 μm.

Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322

GTX103322 WB Image

Orthogonal

Untreated (–) and treated (+) RAW264.7 whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with NRF2 antibody [N2C2], Internal (GTX103322) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-NRF2 antibody [N2C2], Internal used in Immunoprecipitation (IP). GTX103322

GTX103322 IP Image

Immunoprecipitation of NRF2 protein from HepG2 whole cell extracts using 5 μg of NRF2 antibody [N2C2], Internal (GTX103322).
Western blot analysis was performed using NRF2 antibody [N2C2], Internal (GTX103322) diluted at 1:500.
EasyBlot anti-Rabbit IgG (GTX221666-01) was used as a secondary reagent.

Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322

GTX103322 WB Image

Orthogonal

Untreated (–) and treated (+) Neuro2A whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with NRF2 antibody [N2C2], Internal (GTX103322) diluted at 1:2000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322

GTX103322 WB Image

Orthogonal

Untreated (–) and treated (+) Rat2 whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with NRF2 antibody [N2C2], Internal (GTX103322) diluted at 1:2000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.

Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322

GTX103322 WB Image

Orthogonal

Untreated (–) and treated (+) HepG2 whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with NRF2 antibody [N2C2], Internal (GTX103322) diluted at 1:2000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-NRF2 antibody [N2C2], Internal used in IHC (Paraffin sections) (IHC-P). GTX103322

GTX103322 IHC-P Image

Orthogonal

The data was published in the journal Redox Biol in 2017.PMID: 28448946

Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322

GTX103322 WB Image

Orthogonal

The data was published in the journal PLoS One in 2016.PMID: 27023634

Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322

GTX103322 WB Image

KO/KD Orthogonal

The data was published in the journal PLoS One in 2016.PMID: 27023634

Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322

GTX103322 WB Image

Orthogonal

The data was published in the journal PLoS One in 2013. PMID: 24204994

Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322

GTX103322 WB Image

Orthogonal

The data was published in the journal Cells in 2019. PMID: 31366086

Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322

GTX103322 WB Image

The data was published in the journal Int J Mol Sci in 2017. PMID: 28926934

REFERENCE

Application Reference

Y Liu et al. Int J Chronic Obstr 2024; : 1905-1920 Effective-Component Compatibility of Bufei Yishen Formula III Suppresses Mitochondrial Oxidative Damage in COPD: Via Pkm2/Nrf2 Pathway
Chen HX et al. Zool Res 2024; 45 (3) : 478-491 Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field.
A Masato et al. Cell Death Dis 2024; 15 (6) : 424 Sequestosome-1 (SQSTM1/p62) as a target in dopamine catabolite-mediated cellular dyshomeostasis
Hsu WY et al. Antioxidants (Basel) 2024; 13 (4) Deferasirox Causes Leukaemia Cell Death through Nrf2-Induced Ferroptosis.
YL Huang et al. Antioxidants (Basel) 2024; 13 (4) : 481 NLRX1 Inhibits LPS-Induced Microglial Death via Inducing p62-Dependent HO-1 Expression, Inhibiting MLKL and Activating PARP-1
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REVIEW

NRF2 antibody [N2C2], Internal Cat. No. GTX103322

Rating
( Average 5 based on 2 users reviews)
Application
Western Blot(WB)
( Average 5 based on 2 users reviews)
Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322
Date : Anonymous submitted on 15-Nov-2022
Score :
Application Tested : WB
Sample Species : Ms
Sample : mouse hepatocyte
Amount used : 50μg
Blocking : 5% nonfat milk, 20°C, 1Hr
Primary Antibody : 1:1000, 4°C, 12Hr
Anti-NRF2 antibody [N2C2], Internal used in Western Blot (WB). GTX103322
Date : Anonymous submitted on 19-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Sample : LNCaP cells
Amount used : 30 μg
Blocking : 5% non-fat milk in TBST, RT°C, 1Hr
Primary Antibody : 1:1000, 4°C, 16Hr
Lane Description :
Lane1: Control (24 h after irradiation with 0 Gy)
Lane2: 24 h after irradiation with 2 Gy
Lane3: 24 h after irradiation with 4 Gy
Lane4: 24 h after irradiation with 8 Gy
Submit a Review
Application Reference
Y Liu et al. Int J Chronic Obstr 2024;:1905-1920 Effective-Component Compatibility of Bufei Yishen Formula III Suppresses Mitochondrial Oxidative Damage in COPD: Via Pkm2/Nrf2 Pathway
Chen HX et al. Zool Res 2024; 45 (3):478-491 Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field.
A Masato et al. Cell Death Dis 2024; 15 (6):424 Sequestosome-1 (SQSTM1/p62) as a target in dopamine catabolite-mediated cellular dyshomeostasis
Hsu WY et al. Antioxidants (Basel) 2024; 13 (4) Deferasirox Causes Leukaemia Cell Death through Nrf2-Induced Ferroptosis.
YL Huang et al. Antioxidants (Basel) 2024; 13 (4):481 NLRX1 Inhibits LPS-Induced Microglial Death via Inducing p62-Dependent HO-1 Expression, Inhibiting MLKL and Activating PARP-1
Li D et al. Heliyon 2024; 10 (5):e27644 DL-3-n-butylphthalide attenuates doxorubicin-induced acute cardiotoxicity via Nrf2/HO-1 signaling pathway.
Hirota K et al. J Biol Chem 2023; 299 (12):105478 miR-125a-5p/miR-125b-5p contributes to pathological activation of angiotensin II-AT1R in mouse distal convoluted tubule cells by the suppression of Atrap.
S Li et al. Research Square 2023; Integration of transcriptomics and proteomics uncovers novel targets underlying the protective effects of Nrf2 knockout in HEI-OC1 cells
Application : WB
Sulistyowati E et al. Int J Mol Sci 2023; 24 (21) Vasculoprotective Potential of Baicalein in Angiotensin II-Infused Abdominal Aortic Aneurysms through Inhibiting Inflammation and Oxidative Stress.
Li LX et al. Food Chem Toxicol 2023; 182:114198 Allyl methyl disulfide (AMDS) prevents N,N-dimethyl formamide-induced liver damage by suppressing oxidative stress and NLRP3 inflammasome activation
Application : WB
Reactivity : Mouse
I Hirasawa et al. PLoS One 2023; Anti-inflammatory effects of cold atmospheric plasma irradiation on the THP-1 human acute monocytic leukemia cell line
Application : WB
CW Park et al. Research Square 2023; Targeting Bone Marrow Lipid Metabolism with Adiponectin Receptor Agonist for Diabetic and Postmenopausal Osteoporosis
Application : WB
AS Arellano Buendia et al. PeerJ 2023; Antioxidant and anti-inflammatory effects of allicin in the kidney of an experimental model of metabolic syndrome
Al-Zahaby SA et al. Animals (Basel) 2023; 13 (18) Zinc Oxide Nanoparticles (ZnO-NPs) Induce Cytotoxicity in the Zebrafish Olfactory Organs via Activating Oxidative Stress and Apoptosis at the Ultrastructure and Genetic Levels.
S?nchez-Gloria JL et al. Int J Mol Sci 2023; 24 (16) Allicin, an Emerging Treatment for Pulmonary Arterial Hypertension: An Experimental Study.
Abd El-Emam MM et al. Antioxidants (Basel) 2023; 12 (8) The Potential Effects of Quercetin-Loaded Nanoliposomes on Amoxicillin/Clavulanate-Induced Hepatic Damage: Targeting the SIRT1/Nrf2/NF-κB Signaling Pathway and Microbiota Modulation.
Liu S et al. Nutrients 2023; 15 (9) Sulforaphane Inhibits Foam Cell Formation and Atherosclerosis via Mechanisms Involving the Modulation of Macrophage Cholesterol Transport and the Related Phenotype.
Richard J. Bloomer et al. Processes 2023; 11 (7):2011 Alpha Hope, via Molecular Hydrogen and Pyrroloquinoline Quinone, Dose-Dependently Increases Nrf2 and PGC-1α Levels in C2C12 Myoblasts
Application : WB
Zhang H et al. Biomol Biomed 2023; 23 (3):457-470 Sivelestat sodium attenuates acute lung injury by inhibiting JNK/NF-κB and activating Nrf2/HO-1 signaling pathways.
Nat Prod Res 2023; 18 (5):1–10 Phillyrin Ameliorates Oxidative Stress in D-Galactose-Induced Senescence in the Brain of Mice by Regulating the Nrf2/ HO-1 Signaling Pathway
Application : WB
Reactivity : Mouse
Ibrahim Fouad G et al. Cardiovasc Toxicol 2023; 23 (1):46-60 Sulforaphane, an Nrf-2 Agonist, Modulates Oxidative Stress and Inflammation in a Rat Model of Cuprizone-Induced Cardiotoxicity and Hepatotoxicity.
Application : IHC-P
Reactivity : Rat
Richter FC et al. EMBO J 2023; 42 (6):e112202 Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL-10.
Ren J et al. Acta Biochim Biophys Sin (Shanghai) 2022; 54 (1):77-90 MEF2C ameliorates learning, memory, and molecular pathological changes in Alzheimer’s disease in vivo and in vitro.
Application : WB
Reactivity : Mouse
Hsu WL et al. Cell Death Dis 2022; 13 (12):1060 Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through p62-Keap-1-Nrf2 axis.
Jayakumar T et al. Molecules 2022; 27 (16) Activation of Nrf2 by Esculetin Mitigates Inflammatory Responses through Suppression of NF-κB Signaling Cascade in RAW 264.7 Cells.
Wang H et al. J Cardiovasc Pharmacol 2022; 80 (4):609-615 Sestrin2 Is Increased in Calcific Aortic Disease and Inhibits Osteoblastic Differentiation in Valvular Interstitial Cells via the Nuclear Factor E2-related Factor 2 Pathway.
Rajendiran A et al. Antioxidants (Basel) 2022; 11 (12) NRF2/Itaconate Axis Regulates Metabolism and Inflammatory Properties of T Cells in Children with JIA.
Application : WB, FACS
Reactivity : Human
Abe E et al. Sci Rep 2022; 12 (1):17376 Angiotensin II type-1 receptor-associated protein interacts with transferrin receptor-1 and promotes its internalization.
Application : WB
Reactivity : Human
Wang SH et al. Antioxidants (Basel) 2022; 11 (9) Prinsepiae Nux Extract Activates NRF2 Activity and Protects UVB-Induced Damage in Keratinocyte.
Wang H et al. Acta Pharm Sin B 2022; 12 (4):1871-1884 Nuclear TIGAR mediates an epigenetic and metabolic autoregulatory loop via NRF2 in cancer therapeutic resistance.
Pedro Garc?a-G?mez et al. Mol Oncol 2022; 16 (9):1891-1912 NOX4 regulates TGFβ-induced proliferation and self-renewal in glioblastoma stem cells.
Application : WB
Reactivity : Human
Kun Cao et al. Med Sci Monit 2022; 28:e933978 Activation of α7 Nicotinic Acetylcholine Receptor by its Selective Agonist Improved Learning and Memory of Amyloid Precursor Protein/Presenilin 1 (APP/PS1) Mice via the Nrf2/HO-1 Pathway.
Application : WB
Reactivity : Mouse
Huidan Zhang et al. J Inflamm Res 2022; 15:2103-2119 Gut Microbiota Mediates the Susceptibility of Mice to Sepsis-Associated Encephalopathy by Butyric Acid.
Lin JH et al. Oxid Med Cell Longev 2022; 2022:9523491 Xanthohumol Protects the Rat Myocardium against Ischemia/Reperfusion Injury-Induced Ferroptosis.
Application : WB
Reactivity : Rat
Wei-Chun Chen et al. Viruses 2021; 13 (4) (E)-Guggulsterone Inhibits Dengue Virus Replication by Upregulating Antiviral Interferon Responses through the Induction of Heme Oxygenase-1 Expression.
Application : WB
Reactivity : Human
Han Wang et al. Mol Med Rep 2021; 24 (1) Transforming growth factor?β1 functions as a competitive endogenous RNA that ameliorates intracranial hemorrhage injury by sponging microRNA?93?5p.
Application : WB
Reactivity : Human
Ting-Yu Chao et al. Food Sci Nutr 2021; 9 (9):4758-4769 Bracteanolide A abrogates oxidative stress-induced cellular damage and protects against hepatic ischemia and reperfusion injury in rats.
Application : WB
Reactivity : Human
Anna Piovan et al. Front Pharmacol 2021; 12:724993 Pre- and Early Post-treatment With Arthrospira platensis (Spirulina) Extract Impedes Lipopolysaccharide-triggered Neuroinflammation in Microglia.
Application : ICC/IF
Reactivity : Mouse
Liu Y et al. Front Pharmacol 2021; 12:739220 Tetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis.
Application : ChIP assay
Reactivity : Mouse
Lin JH et al. Biomolecules 2021; 11 (11) Gossypol Acetic Acid Attenuates Cardiac Ischemia/Reperfusion Injury in Rats via an Antiferroptotic Mechanism.
Application : WB
Reactivity : Rat
She H et al. J Inflamm Res 2021; 14:6765-6782 Protective Effects of Dexmedetomidine on Sepsis-Induced Vascular Leakage by Alleviating Ferroptosis via Regulating Metabolic Reprogramming.
Reactivity : Rat
Yoon JH et al. Biomed Pharmacother 2021; 144:112271 Protective effect of sargahydroquinoic acid against Aβ25-35-evoked damage via PI3K/Akt mediated Nrf2 antioxidant defense system.
Zhu Z et al. Oxid Med Cell Longev 2021; 2021:1394486 Mitoquinone Protects Podocytes from Angiotensin II-Induced Mitochondrial Dysfunction and Injury via the Keap1-Nrf2 Signaling Pathway.
Application : IHC-P
Reactivity : Mouse
Song L et al. Brain Res Bull 2021; 177:81-91 Antidepressant effect of catalpol on corticosterone-induced depressive-like behavior involves the inhibition of HPA axis hyperactivity, central inflammation and oxidative damage probably via dual regulation of NF-κB and Nrf2.
Application : WB
Reactivity : Mouse
Raineri A et al. Molecules. 2021; 26 (16):5027 3,5-Dicaffeoylquinic Acid Lowers 3T3-L1 Mitotic Clonal Expansion and Adipocyte Differentiation by Enhancing Heme Oxygenase-1 Expression.
Application : WB
Reactivity : Mouse
Hsieh CH et al. Theranostics 2021; 11 (14):7072-7091 An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment.
Application : ChIP assay
Reactivity : Human
Zeng J et al. Phytother Res 2021; 35 (6):3418-3427 Theaflavin alleviates oxidative injury and atherosclerosis progress via activating microRNA-24-mediated Nrf2/HO-1 signal.
Application : WB
Li D et al. Life Sci 2021; 277:119467 Maresin 1 alleviates the inflammatory response, reduces oxidative stress and protects against cardiac injury in LPS-induced mice.
Application : WB
Reactivity : Mouse
Islam J et al. Int Immunopharmacol 2021; 96:107566 Taxifolin ameliorates Benzo[a]pyrene-induced lung injury possibly via stimulating the Nrf2 signalling pathway.
Chen YS et al. Antioxidants (Basel) 2021; 10 (4) Identification of Beilschmiedia tsangii Root Extract as a Liver Cancer Cell-Normal Keratinocyte Dual-Selective NRF2 Regulator.
Application : WB
Hung K.W. et al. Appl. Sci. 2021; 11 (3):1008 TQ-6, a Novel Ruthenium Derivative Compound, Possesses Potent Free Radical Scavenging Activity in Macrophages and Rats.
Terasaki M et al. Nutr Cancer 2021;:1-16 A Marine Carotenoid of Fucoxanthinol Accelerates the Growth of Human Pancreatic Cancer PANC-1 Cells.
Terasaki M et al. Cancer Genomics Proteomics 2021; 18 (2):133-146 A Fucoxanthinol Induces Apoptosis in a Pancreatic Intraepithelial Neoplasia Cell.
Application : WB
Reactivity : Mouse
Deng S et al. Oxid Med Cell Longev 2021; 2021:8891373 Albumin Reduces Oxidative Stress and Neuronal Apoptosis via the ERK/Nrf2/HO-1 Pathway after Intracerebral Hemorrhage in Rats.
Application : WB
Reactivity : Mouse
Liu M et al. Mol Neurobiol 2021; (Epub) Cottonseed Oil Alleviates Ischemic Stroke-Induced Oxidative Stress Injury Via Activating the Nrf2 Signaling Pathway.
Application : WB
Liu S et al. Oxid Med Cell Longev 2021; 2021:5913424 IL-20R Activation via rIL-19 Enhances Hematoma Resolution through the IL-20R1/ERK/Nrf2 Pathway in an Experimental GMH Rat Pup Model.
Application : WB
Reactivity : Rat
Garc?a-Arroyo FE et al. Int J Mol Sci 2021; 22 (5) Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet.
Application : WB
Reactivity : Mouse
Fernando E Garc?a-Arroyo et al. Oxid Med Cell Longev 2020; 2020:8850266 Fluid Intake Restriction Concomitant to Sweetened Beverages Hydration Induce Kidney Damage.
Application : WB
Reactivity : Rat
Arellano-Buend?a AS et al. Antioxidants (Basel) 2020; 9 (11) Effects of Allicin on Pathophysiological Mechanisms during the Progression of Nephropathy Associated to Diabetes.
Application : WB
Reactivity : Rat
Huang JL et al. Phytother Res 2020; (Epub) Salviplenoid A from Salvia plebeia attenuates acute lung inflammation via modulating NF-κB and Nrf2 signaling pathways.
Application : WB
Reactivity : Mouse
Chen HY et al. Chem Biol Interact 2020; 331:109249 TGF-β1 signaling protects retinal ganglion cells from oxidative stress via modulation of the HO-1/Nrf2 pathway.
Application : WB
Reactivity : Mouse
Seiwert N et al. Cell Death Dis 2020; 11 (9):787 Heme oxygenase 1 protects human colonocytes against ROS formation, oxidative DNA damage and cytotoxicity induced by heme iron, but not inorganic iron.
Application : WB
Reactivity : Human
Deng S et al. Neurotherapeutics 2020; (Epub) Recombinant CCL17 Enhances Hematoma Resolution and Activation of CCR4/ERK/Nrf2/CD163 Signaling Pathway After Intracerebral Hemorrhage in Mice.
Application : WB
Reactivity : Mouse
Batubara I et al. Antioxidants (Basel) 2020; 9 (8) The Antiaging Effect of Active Fractions and Ent-11α-Hydroxy-15-Oxo-Kaur-16-En-19-Oic Acid Isolated from Adenostemma lavenia (L.) O. Kuntze at the Cellular Level.
Application : WB
Reactivity : Mouse
Huang X et al. Toxicol Mech Methods 2020; 30 (8):580-589 The protective role of Nrf2 against aristolochic acid-induced renal tubular epithelial cell injury.
Application : WB
Reactivity : Rat
Endo H et al. Redox Biol 2020; 36:101643 Metabolic reprogramming sustains cancer cell survival following extracellular matrix detachment.
Application : WB
Reactivity : Human
Kuang Y et al. Mol Med Rep 2020; 22 (4):2783-2790 Protective effect of dimethyl fumarate on oxidative damage and signaling in cardiomyocytes.
Application : WB
Reactivity : Rat
Chou YJ et al. Sci Rep 2020; 10 (1):8422 Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy.
Application : WB
Reactivity : Mouse
Yang F et al. Br J Cancer 2020; 122 (12):1791-1802 Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation.
Application : WB
Reactivity : Mouse
Tsai TF et al. Drug Des Devel Ther 2020; 14:1209-1218 Miconazole Contributes to NRF2 Activation by Noncanonical P62-KEAP1 Pathway in Bladder Cancer Cells.
Application : ICC/IF
Reactivity : Human
Su YC et al. FASEB J 2020; 34 (6):7283-7294 MicroRNA-155 inhibits dengue virus replication by inducing heme oxygenase-1-mediated antiviral interferon responses.
Application : WB
Reactivity : Human
Dongil P et al. Aging (Albany NY) 2020; 12 (3):2275-2301 PAS kinase deficiency reduces aging effects in mice.
Application : WB
Reactivity : Mouse
Ungerer G et al. Neuromolecular Med 2020; (Epub) Harpagophytum procumbens Extract Ameliorates Allodynia and Modulates Oxidative and Antioxidant Stress Pathways in a Rat Model of Spinal Cord Injury.
Application : WB
Reactivity : Rat
Caihong Wang et al. Chemosphere 2020; 241 Triclosan-induced liver and brain injury in zebrafish (Danio rerio) via abnormal expression of miR-125 regulated by PKCα/Nrf2/p53 signaling pathways.
Application : IHC-P
Reactivity : Zebrafish
Ast T et al. Cell 2019; 177 (6):1507-1521.e16 Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis.
Guo X et al. Front Neurol 2019; 10:271 Hydralazine Protects Nigrostriatal Dopaminergic Neurons From MPP+ and MPTP Induced Neurotoxicity: Roles of Nrf2-ARE Signaling Pathway.
Application : IHC-P
Reactivity : Mouse
Geng X et al. Mol Neurobiol 2019; (Epub) Effects of Docosahexaenoic Acid and Its Peroxidation Product on Amyloid-帣 Peptide-Stimulated Microglia.
Application : WB
Reactivity : Mouse
Gandhi KA et al. Free Radic Biol Med 2019; 145:8-19 Oral administration of 3,3'-diselenodipropionic acid prevents thoracic radiation induced pneumonitis in mice by suppressing NF-kB/IL-17/G-CSF/neutrophil axis.
Application : IHC-P
Reactivity : Mouse
Neitzel C et al. Cells 2019; 8 (8) Lipoic Acid Synergizes with Antineoplastic Drugs in Colorectal Cancer by Targeting p53 for Proteasomal Degradation.
Application : WB
Reactivity : Human
Rashidi Z et al. Reprod Biol 2019; Quercetin protects human granulosa cells against oxidative stress via thioredoxin system.
Application : WB
Reactivity : Human
Singh MV et al. Circulation. 2019; 139 (9):1199-1216 Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals.
Application : WB
Reactivity : Mouse
Muszy?ska B et al. Biol Trace Elem Res 2019; (Epub) Lentinula edodes as a Source of Bioelements Released into Artificial Digestive Juices and Potential Anti-inflammatory Material.
Application : WB
Reactivity : Mouse
Chen WC et al. J Viral Hepat 2019; (Epub) MicroRNA-let-7c suppresses hepatitis C virus replication by targeting Bach1 for induction of haem oxygenase-1 expression.
Application : WB
Reactivity : Human
Luo M et al. Cell Metab 2018; 28 (1):69-86.e6 Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling.
Cai J et al. Cell Rep 2018; 25 (7):1708-1717.e5 autophagy ablation in adipocytes induces * resistance and reveals roles for lipid peroxide and nrf2 signaling in adipose-liver crosstalk.
Application : WB
Reactivity : Mouse
Selim SA et al. Histochem Cell Biol 2018; (Epub) Bone marrow-derived mesenchymal stem cells ameliorate liver injury in a rat model of sepsis by activating Nrf2 signaling.
Application : IHC-P
Reactivity : Rat
Liu L et al. Fish Shellfish Immunol 2018; 83:386-396 Antiviral effect of 7-(4-benzimidazole-butoxy)-coumarin on rhabdoviral clearance via Nrf2 activation regulated by PKCα/β phosphorylation.
Application : ICC/IF
Bo?ena Muszy?ska et al. European Food Research and Technology 2018;:43110 Study of biological activity of Tricholoma equestre fruiting bodies and their safety for human.
Application : WB
Reactivity : Human
Endo H et al. Sci Rep 2018; 8 (1):10122 Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells.
Application : WB
Reactivity : Human
Huang KF et al. J Cell Physiol 2018; (Epub) A new copper ionophore DPMQ protects cells against ultraviolet B irradiation by inhibiting the TRPV1 channel.
Application : WB
Reactivity : Human
Finger JW Jr et al. Arch Environ Contam Toxicol 2018; (Epub) Dietary Selenomethionine Administration and Its Effects on the American Alligator (Alligator mississippiensis): Oxidative Status and Corticosterone Levels.
Application : WB
Reactivity : Alligator
Muszynska B et al. International Journal of Medicinal Mushrooms 2018; (Epub) The Anti-Inflammatory Potential of In Vitro Cultures of White Button Mushroom, Agaricus bisporus (Agaricomycetes) in Caco-2 Cells.
Application : WB
Akizuki R et al. Biochim Biophys Acta 2018; 1865 (5):769-780 decrease in paracellular permeability and chemosensitivity to * by claudin-1 in spheroid culture models of human lung adenocarcinoma a549 cells.
Application : WB
Reactivity : Human
Fragoulis A et al. Redox Biol 2017; 12:843-853 Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease.
Lin JT et al. Food Funct. 2017; 8 (3):1245-1253 Molecular mechanisms of the effects of the ethanolic extract of Muntingia calabura Linn. fruit on lipopolysaccharide-induced pro-inflammatory mediators in macrophages.
Application : WB
Reactivity : Plant
Yang HL et al. Biochem Pharmacol 2017; 148:130-146 Zerumbone protects human skin keratinocytes against UVA-irradiated damages through Nrf2 induction.
Application : WB
Reactivity : Human
Maruhashi R et al. Biochim Biophys Acta 2017; 1865 (3):470-479 Elevation of sensitivity to anticancer agents of human lung adenocarcinoma A549 cells by knockdown of claudin-2 expression in monolayer and spheroid culture models.
Application : WB
Reactivity : Human
Finger JW Jr et al. Bull Environ Contam Toxicol 2017; (Epub) No Effect of Lifelong Methylmercury Exposure on Oxidative Status in Zebra Finches (Taeniopygia guttata): A Demonstration of Methylmercury-Induced Selection?
Application : WB
Reactivity : Bird
Tseng CK et al. Antiviral Res 2017; 146:191-200 Celastrol inhibits hepatitis C virus replication by upregulating heme oxygenase-1 via the JNK MAPK/Nrf2 pathway in human hepatoma cells.
Application : WB
Reactivity : Human
Zhang Y et al. Am J Physiol Regul Integr Comp Physiol 2017;:ajpregu.00176.2017 A mitohormetic response to pro-oxidant exposure in the house mouse.
Application : WB
Reactivity : Mouse
Garcia Trejo EMA et al. Int J Mol Sci 2017; 18 (9) The Beneficial Effects of Allicin in Chronic Kidney Disease Are Comparable to Losartan.
Application : WB
Reactivity : Rat
RowleyIV T et al. J Nutr Biochem 2017; (Epub) Monomeric cocoa catechins enhance β-cell function by increasing mitochondrial respiration.
Application : WB, ICC/IF
Reactivity : Rat
Chen YW et al. Kaohsiung J Med Sci. 2017; (Epub) High Nrf2 expression in alveolar type I pneumocytes is associated with low recurrences in primary spontaneous pneumothorax.
Application : IHC-P
Reactivity : Human
Liu L et al. Antiviral Res 2017; (Epub) Evaluation on antiviral activity of coumarin derivatives against spring viraemia of carp virus in epithelioma papulosum cyprini cells.
Application : WB
Choi EJ et al. Oncogene 2017; (Epub) A clinical drug library screen identifies * propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer.
Application : WB
Reactivity : Human
Tsai TH et al. Molecules 2017; 22 (5) Protective Effect of Caffeic Acid Derivatives on tert-Butyl Hydroperoxide-Induced Oxidative Hepato-Toxicity and Mitochondrial Dysfunction in HepG2 Cells.
Application : WB
Reactivity : Human
Ehecatl M. A. Garcia-Trejo et al. Oxid Med Cell Longev 2016; 2016:Article ID 3850402 Effects of Allicin on Hypertension and Cardiac Function in Chronic Kidney Disease.
Application : IHC-P
Reactivity : Rat
Draheim T et al. Glia 2016; Activation of the astrocytic Nrf2/ARE system ameliorates the formation of demyelinating lesions in a multiple sclerosis animal model.
Application : IHC-P
Reactivity : Mouse
Tapia E et al. Free Radic Res 2016; 50 (7):781-92 Mycophenolate mofetil and curcumin provide comparable therapeutic benefit in experimental chronic kidney disease: role of Nrf2-Keap1 and renal * pathways.
Application : WB
Reactivity : Rat
Wu KL et al. Free Radic Biol Med 2016; 97:58-74 Impaired Nrf2 regulation of mitochondrial biogenesis in rostral ventrolateral medulla on hypertension induced by systemic inflammation.
Application : WB
Reactivity : Rat
Asada D et al. Pediatr Int 2016; (Epub) The tolerance to ischemia reperfusion injury in a congenital heart disease model.
Application : WB
Reactivity : Rat
Yu JS et al. PLoS One 2016; 11 (3):e0152236 Sulforaphane Suppresses Hepatitis C Virus Replication by Up-Regulating Heme Oxygenase-1 Expression through PI3K/Nrf2 Pathway.
Application : WB
Reactivity : Human
Wang YL et al. J Ethnopharmacol 2015; 162:168-75 Celastrol prevents circulatory failure via induction of heme oxygenase-1 and heat shock protein 70 in endotoxemic rats.
Application : WB
Reactivity : Rat
Lee JC et al. Br J Pharmacol 2014; 171 (1):237-52 Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells.
Application : WB
Reactivity : Human
Suwanna N et al. EXCLI J 2014; 13:1097-103 Neuroprotection by diarylpropionitrile in mice with spinal cord injury.
Application : WB
Reactivity : Mouse
Gianluigi Zaza et al. PLoS One. 2013; 8 (10) Downregulation of nuclear-encoded genes of oxidative metabolism in dialyzed chronic kidney disease patients
Application : WB
Reactivity : Human
Lin YS et al. Biochem Pharmacol 2013; 86 (2):242-52 The suppression of thoc1 in cancer cell apoptosis mediated by activated macrophages is nitric oxide-dependent.
Application : WB
Reactivity : Mouse
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