GeneTex
United States (US)

NSD2 antibody [N1], N-term

GTX106306_WB_19011506_776.jpg
GTX106306_IHC_19011506_388.jpg

Cat No. GTX106306

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:3000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

152 kDa. ( Note )

Positive Control

Molt-4 , Raji

Predict Reactivity

Mouse(>80% identity)
PROPERTIES

Form

Liquid

Buffer

0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human NSD2. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

FLJ23286 antibody, KIAA1090 antibody, MGC176638 antibody, MMSET antibody, NSD2 antibody, REIIBP antibody, TRX5 antibody, WHS antibody, WHSC1 antibody, nuclear SET domain-containing protein 2 antibody, probable histone-lysine N-methyltransferase NSD2 antibody, trithorax/ash1-related protein 5 antibody, IL5 promoter REII region-binding protein antibody, multiple myeloma SET domain containing protein type III antibody, Wolf-Hirschhorn syndrome candidate 1 antibody

Background

This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq]

Database

Research Area

DATA IMAGES
GTX106306_WB_19011506_776.jpg

GTX106306 WB Image

Sample(30 ug whole cell lysate)
A:Raji (GTX27908)
5% SDS PAGE
GTX106306 diluted at 1:1000

GTX106306_IHC_19011506_388.jpg

GTX106306 IHC-P Image

Immunohistochemical analysis of paraffin-embedded A549 xenograft, using NSD2(GTX106306) antibody at 1:100 dilution.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

SDS
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 319
$ 169