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Nav1.5 antibody

Anti-Nav1.5 antibody used in IHC (Frozen sections) (IHC-Fr). GTX54798
Anti-Nav1.5 antibody used in Western Blot (WB). GTX54798
Anti-Nav1.5 antibody used in Western Blot (WB). GTX54798
Anti-Nav1.5 antibody used in IHC (Paraffin sections) (IHC-P). GTX54798

Cat. No. GTX54798

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, IHC-Fr, IP

Reactivity

 Human, Mouse, Rat
Package
50 μl ($639)
See all Nav1.5 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-P Assay dependent
IHC-Fr Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

227 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.8 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Immunogen

Peptide DRLPKSDSEDGPRALNQLS(C), corresponding to amino acid residues 493-511 (Intracellular loop between domains I and II) of  rat NaV1.5 (accession number P15389).

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

sodium voltage-gated channel alpha subunit 5 , Nav1.5 , SCAL

Cellular Localization

Cell membrane

Background

acts as a tetrodotoxin-resistant voltage gated sodium channel; may play a role in cardiac function [RGD, Feb 2006]

Database

Research Area

DATA IMAGES

Anti-Nav1.5 antibody used in IHC (Frozen sections) (IHC-Fr). GTX54798

GTX54798 IHC-Fr Image

IHC-Fr analysis of mouse heart tissue using GTX54798 Nav1.5 antibody. NaV1.5 staining (green) is part of the striate morphology. Nuclei are stained with DAPI (blue).
Dilution : 1:200

Anti-Nav1.5 antibody used in Western Blot (WB). GTX54798

GTX54798 WB Image

WB analysis of NaV1.5 transfected HEK-293 cell lysate using GTX54798 Nav1.5 antibody preincubated with or without immunogen peptide.
Dilution : 1:200

Anti-Nav1.5 antibody used in Western Blot (WB). GTX54798

GTX54798 WB Image

WB analysis of rat heart membrane lysate using GTX54798 Nav1.5 antibody preincubated with or without immunogen peptide.
Dilution : 1:200

Anti-Nav1.5 antibody used in IHC (Paraffin sections) (IHC-P). GTX54798

GTX54798 IHC-P Image

IHC-P analysis of rat heart tissue using GTX54798 Nav1.5 antibody. Staining is specific for cardiomyocytes while smooth muscles cells in the small vessels are negative (red arrows). Hematoxilin is used as the counterstain.
Dilution : 1:100

REFERENCE

Application Reference

Wang T et al. Chin Med J (Engl) 2023; 136 (11) : 1349-1357 Downregulation of cardiac PIASy inhibits Cx43 SUMOylation and ameliorates ventricular arrhythmias in a rat model of myocardial ischemia/reperfusion injury.
Submit a Reference

REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 639