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Nav1.5 antibody

Anti-Nav1.5 antibody used in IHC (Paraffin sections) (IHC-P). GTX54803
Anti-Nav1.5 antibody used in Western Blot (WB). GTX54803

Cat. No. GTX54803

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, FACS

Reactivity

 Human, Rat
Package
50 μl ($639)
See all Nav1.5 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-P Assay dependent
FACS Assay dependent
Not tested in other applications.

Calculated MW

227 kDa. ( Note )

Predict Reactivity

Mouse(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.95 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

GST  fusion protein with amino acid residues 1978-2016 (Intracellular, C-terminus) of human NaV1.5 (Accession Q14524), (MW: 33 kDa.).

Purification

Depleted of anti-GST antibodies by affinity chromatography on immobilized GST and purified by antigen-affinity chromatography.
From serum

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

sodium voltage-gated channel alpha subunit 5 , CDCD2 , CMD1E , CMPD2 , HB1 , HB2 , HBBD , HH1 , ICCD , IVF , LQT3 , Nav1.5 , PFHB1 , SSS1 , VF1

Cellular Localization

Cell membrane

Background

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Nav1.5 antibody used in IHC (Paraffin sections) (IHC-P). GTX54803

GTX54803 IHC-P Image

IHC-P analysis of rat cardiac muscle tissue using GTX54803 Nav1.5 antibody. Staining is specific for cardiomyocytes while smooth muscles cells in the artery walls are negative (red arrows). Hematoxilin is used as the counterstain.
Dilution : 1:100

Anti-Nav1.5 antibody used in Western Blot (WB). GTX54803

GTX54803 WB Image

WB analysis of NaV1.5 transfected HEK-293 cell lysate using GTX54803 Nav1.5 antibody preincubated with or without immunogen peptide.
Dilution : 1:200

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 639