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Nav1.6 antibody

Anti-Nav1.6 antibody used in IHC (Frozen sections) (IHC-Fr). GTX54842
Anti-Nav1.6 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX54842
Anti-Nav1.6 antibody used in Western Blot (WB). GTX54842

Cat No. GTX54842

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-Fr

Reactivity

 Human, Mouse, Rat
Package
50 μl ($549)
See all Nav1.6 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-Fr Assay dependent
Not tested in other applications.

Calculated MW

225 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS pH 7.4, 1% BSA, 0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.8 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Immunogen

Peptide CIANHTGVDIHRNGDFQKNG, corresponding to amino acid residues 1042-1061 (Intracellular loop between domains II and III) of rat NaV1.6 (Accession  : O88420).

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

RRID

AB_2887892

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

sodium voltage-gated channel alpha subunit 8

Cellular Localization

Cell membrane

Background

tetrodotoxin-sensitive sodium channel alpha subunit [RGD, Feb 2006]

Database

Research Area

DATA IMAGES

Anti-Nav1.6 antibody used in IHC (Frozen sections) (IHC-Fr). GTX54842

GTX54842 IHC-Fr Image

IHC-Fr analysis of mouse hippocampus tissue using GTX54842 Nav1.6 antibody. DAPI is used as the counterstain.
Panel A : NaV1.6 (green) is robustly expressed in the CA1 pyramidal layer (white arrows).
Panel B : Staining with mouse anti-parvalbumin (red), a marker of interneurons.
Panel C : Merged image of panels A and B  reveals that NaV1.6 appears in some interneurons (arrow) but is not restricted to interneurons.

Anti-Nav1.6 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX54842

GTX54842 ICC/IF Image

ICC/IF analysis of PFA-fixed rat DRG primary cells using GTX54842 Nav1.6 antibody.
Panel A : Primary antibody
Panel B : DNA dye Hoechst 33342
Panel C : Merged images of panels A and B
Dilution : 1:200

Anti-Nav1.6 antibody used in Western Blot (WB). GTX54842

GTX54842 WB Image

WB analysis of rat brain membrane lysates using GTX54842 Nav1.6 antibody preincubated with or without immunogen peptide.
Dilution : 1:200

REFERENCE

Application Reference

S?nchez-Aguilera A et al. Neuroscience 2020; 442 : 151-167 Development of Action Potential Waveform in Hippocampal CA1 Pyramidal Neurons.
Application : WB
Reactivity : Rat
Submit a Reference

REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 549